【Abstract】 Objective To explore clinical effect of recombinant bovine basic fibroblast growth factor (rb-bFGF) combined with Alginate dressings in treatment of elderly patients with chronic ulcers. Methods Of eligible elderly patients with chronic ulcers according to the order of treatment were randomly assigned to combined group (rb-bFGF combined with alginate dressing treatment group)，bFGF group(rb-bFGF treatment group) and conventional group (conventional treatment group).Comparison of the treatment period: exudate amount，color，granulation，and the healing rate of wound at 1，7，14，21d.the visual analog pain score (VAPS) scores at 1，7d，the quality of life (QOL) score at 1，14d and the self-evaluation of patients about the treatment at 14d. Results 90 patients were enrolled，30 patients in each group. the wound exudate significantly reduced，granulation active，wound ruddy color about the combined group at 7d.bFGF group had a similar change，but not as good as the combined group was significantly(P＜0.05).The new epithelium crawlling faster to wound center，wound contraction and re-epithelialization obvious at 21d，the combined group and bFGF group could significantly promote wound healing，(57.2±7.1)% and (44.9±8.4)% separately of the healing rate of wound were Significantly higher than (21.6±9.6)% of the conventional group，which the difference was statistically significant (P＜0.05).Wound pain of the combined group was significantly relief than the bFGF group and the conventional group at 7d（P＜0.05）；There was a significant difference the QOL score and the effects of self-evaluation of patients about the the combinated group and bFGF group than the conventional group at 14d（P＜0.05），which the combined group was better than the bFGF group. Conclusion rb-bFGF combined with alginate dressing in regulating wound exudate amount，promoting granulation tissue growth and accelerating re-epithelialization which has obvious synergies；while reduci