伊曲康唑与氟康唑预防成人急性白血病（AL）侵袭性真菌感染的疗效比较-现代医学

伊曲康唑与氟康唑预防成人急性白血病（AL）侵袭性真菌感染的疗效比较

单位：四川省泸州市泸州医学院附属医院血液内科

分类号：

出版年·卷·期（页码）：2012·40·第一期（42-44）

摘要：

摘要：目的: 探索临床预防侵袭性真菌感染的有效方法。方法：采用非随机同期对照实验的方法将符合实验标准的84例急性白血病患者分为实验组和对照组。实验组给予伊曲康唑200mg/次，口服，1次/天，共15天；对照组给予氟康唑，150mg/次，口服，1次/天，共15天，以预防真菌感染。结果：实验组和对照组用药前后ALT、总胆红素和血肌酐比较P＞0.05，差异没有统计学意义。两组间真菌感染（确诊+临床诊断+拟诊）率分别为19.0%和40.5%；真菌感染（确诊+临床诊断）率分别为14.3%和33.3%，x2检验结果均显示P＜0.05，可认为两组间真菌感染率具有显著性差异。两组间心电图异常发生率分别为9.5%和4.8%，x2检验结果示P＞0.05，可认为两组间心电图异常发生率不具有显著性差异。结论：伊曲康唑预防真菌感染的发生较氟康唑更具有优越性，并且是安全可靠的。

[Abstract] Objective To evaluate an effective way to clinical prevention of invasive fungal infection. Methods In a non-randomized concurrent control trial, 84 cases of acute leukemia patients who meet the test standard were divided into experimental and control group. Experimental group was given itraconazole in a dose of 200mg once a day for 15 days; control group was given fluconazole in a dose of 150mg once a day for 15 days, to prevent fungal infections. Results Before and after prevention, the ALT, total bilirubin and serum creatinine of experimental and control group, there was a significant diference between the two groups(P＜0.05)．The rate of fungal infection(confirmed, clinical and suspected diagnosis) in experimental group was 19.0%, and 40.5% in control group; the rate of fungal infection(confirmed and clinical diagnosis) in experimental group was 14.3%, and 33.3% in control group, there was a significant difference between the two groups(P＜0.05). The incidence of ECG abnormalities in experimental group was 9.5%, and 4.8% in control group, there was not a significant difference between the two groups(P＞0.05). Conclusions Itraconazole to prevent fungal infection was more superior than fluconazole and was safe and reliable.

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