加巴喷丁治疗带状疱疹后神经痛的临床疗效和安全性观察-现代医学

加巴喷丁治疗带状疱疹后神经痛的临床疗效和安全性观察

单位：首都医科大学宣武医院皮肤性病科

分类号：

出版年·卷·期（页码）：2012·40·第二期（196-198）

摘要：

摘要目的：观察加巴喷丁对国人带状疱疹后神经痛的有效性和安全性。方法：带状疱疹后神经痛病人77例随机分为加巴喷丁组（治疗组）和布洛芬组（对照组），两组病人分别使用加巴喷丁胶囊1800mg/天或布洛芬胶囊600mg/天，总共接受4周的药物治疗。以疼痛缓解程度作为评价疗效的指标。并对治疗过程中出现的不良反应进行评估。结果：加巴喷丁组有效率为72.50%，布洛芬组有效率为48.64%，两组之间疗效差异有显著性意义（P<0.05）。治疗后，加巴喷丁组视觉模拟疼痛评分（VAS）2.28±0.96，布洛芬组VAS评分3.49±1.45，两组间VAS评分比较，差异有非常显著性意义（P<0.01）。加巴喷丁有较好的耐受性，不良反应主要表现为头晕、头昏、嗜睡和转氨酶升高等。结论：加巴喷丁可明显降低带状疱疹后神经痛的程度，并有较好的耐受性。

【Abstract】　Objective　To investigate the effectiveness and safety of Gabapentin in the treatment of postherpefie neuralgia. Methods A total of 77 patients with PHN were randomly divided into control group who received Ibuprofen therapy (n=37) and treatment group who received gabapentin therapy (n=40).The quantification of severity of pain was done using visual analogue scale(VAS) after 4 weeks. Adverse reactions were also observed. Results　The effective rate was 72.50% in the treatment group and 48.64% in the control group with a significant difference between the two groups (P<0•05). The average VAS score was 2•28±0•96 in the treatment group and 3•49±1•45 in the control group with a significant difference between the two groups (P<0•01). Gabapentin was well tolerated, and the most common adverse events were dizziness, vertigo, somnolence and transient abnormality of hepatic function． Conclusion Gabapentin provides significant pain relief in patients of PHN, with very little incidence of adverse reactions.

参考文献：

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录