【Abstract Objective】 Objective To observe the effects of parecoxib sodium of different delivery ways of modified radical mastectomy of breast cancer patients with postoperative morphine analgesia effect. Methods Undergoing modified radical mastectomy of breast cancer patients with 60 cases, aged 45 to 69 years old, ASA I - II, were randomly divided into 2 groups ( n = 30 ) : A group ( preemptive analgesia effects of parecoxib group ) and group B ( parecoxib conventional analgesia group ). Intravenous midazolam, propofol, sufentanil, vecuronium bromide inhalation induction of anesthesia, seven halothane, interrupted administration of sufentanil or vecuronium maintenance of anesthesia. A group before skin incision of 15 intravenous injection of Min first dose of parecoxib sodium 40 mg and 30min operation before the end of the intravenous injection of 0.9% sodium chloride injection of 2ml and 12h interval after intravenous parecoxib sodium 40 mg, group B before skin incision of 15 min intravenous injection of 0.9% sodium chloride injection and operation before the end of the vein of 30min 2ml the first agent of parecoxib sodium 40 mg and 12h interval after intravenous parecoxib sodium 40 mg. After operation two patients were with morphine patient-controlled analgesia ( PCIA ). Recorded after 2, 4, 8, 12, 24 h visual analogue scale ( VAS ), the total number of 24h press and press times, after 24 h morphine consumption and the occurrence of adverse reactions. Results Compared with B group, A group after each time VAS scores showed no significant differences in total, 24h press times and effective pressing significantly reduce the number of times, after 24 h of morphine dosage reduction ( P < 0.05 ), the two groups of patients with adverse reaction of no significant difference ( P > 0.05 ). Conclusion Parecoxib combined with morphine of preemptive analgesia on modified radical mastectomy of breast cancer patients with postoperative analgesia, can reduce the morphine