Objective To investigate the effects of PGZ on inflammatory factors in obesity patients with T2DM．Methods A case-control and a self-controlled study were conducted in 69 obesity patients with T2DM and 50 healthy subjects．Serum inflammatory factors such as CRP,TNF-α,IL-6 and MCP-1 were compared between the two groups，and the changes were measured after treatment with PGZ for 12 weeks．Results Compared with healthy group，obesity patients with T2DM have a notable high levels of inflammatory factors, after treatment with PGZ, the levels decreased significantly. Conclusion PGZ can decrease the levels of inflammatory factors in obesity patients with T2DM．