Objective：Study of Mirrizzi syndrome in laparoscopic cholecystectomy. Method：Laparoscopic cholecystectomy in patients with diagnosis of Mirrizzi syndrome in 12 cases, 4 cases are prospected to have Mirrizzi syndrome preoperatively and the rest were found in LC. Patients who scored Sherry type I underwent laparoscopic cholecystectomy while type II with gallbladder excision plus repair of bile duct or R-Y entrerobiliary anastomosis. By means of curettage and aspiration technique in separation of Calot triangle is recommended. Results：8 cases of Sherry I underwent cholecystectomy. In Type II, 2 of 4 cases received bile duct repair procedure and other 2 with enterobiliary anastomosis. All cases recovered well and have no severe complications after the operations. Conclusion：Mirrizzi syndrome are often encountered during LC. Operative methods are associated with different classification. Application of curettage and aspiration technique in separating Calot triangle can enhance the identifying of the disease and educe bile duct injury. Keyword：Mirrizzi syndrome; LC；Cholecystectomy；Repair of Bile Duct; Enterobiliary Anastomosis.