Objective To investigate the curative efects of early diabetic nephropathy treated with calcium dobesilate and Piperazine Ferulate. Methods 85 patients with early diabetic nephropathy were randomly divided into the treatment and control groups from April 2006 to August 2011,43 cases in treating group，and 42 cases in countrol group.All the patients were given treatment to control blood glucose and 43 patients in the treatment group were treated with calcium dobesilate(500 mg，three times per day)and Piperazine Ferulate(200 mg，three times per day) for 6 months．Urinary albumin excretion(UAE)，Serum glucose，Glyeosylated heamoglobin Alc，Hepatic and renal function,Coagulation function, Serum lipoids level,Thromboxane B2(TXB2) and High-sensitivity C-reactive protein(hs-CRP) were determined before and after the treatment．Results At 3 months After treatment，UAE levels in the treatment group were significantly decreased(P＜0.05), and there were a significant decrease in FIB、 LDL-C、TXB2、hs-CRP,without change in FBG、PBG、HbA1C、hepatic and renal function,in the treatment group at 6 months after treatment，the data had never changed in the control group（P＞0.05）. Conclusion calcium dobesilate conbined with Piperazine Ferulate can decrease the levels of UAE in patients with early diabetic nephropathy and postpone the development of diabetic nephropathy, which might be due to ameliorate hypercoagulation and Micro-inflammatory status through down-regulation FIB、LDL-C、TXB and hs-CRP．