【Abstract】 Objective: To explore the local effect of octreotide on rheumatoid arthritis (RA) in Dark-Agouti (DA) rats. Methods: The study was performed on DA rats. The RA model was established by intracutaneous injection of pristane (300μL) into the root of the tail. After the success of the RA model, octreotide (20M，50L) was injected intraplantarly for four weeks. The curative effect of octreotide on RA was observed. Results: The local injection of octreotide relieved the swelling of the metacarpophalangeal joints, interphalangeal joints and ankles in DA rats, decreased the paw volume, improved the walking disorder, increased range of joint motion, and increased the mechanical withdrawal threshold (MWT). Conclusion: The local injection of octreotide can obtain a remarkable efficacy, relieve the pain and improve the function of the joint.