Objective: To study the clinical significance of serum pyridinoline cross-linked N-telopeptides of type I collagen (NTx), serum bone sialoprotein (BSP) and serum prostate specific antigen (PSA) in diagnosing bone metastasis of prostate cancer. Methods: 73 patients were divided into 2 groups: bone metastasis group (n=38) and non-bone metastasis group(,n= 35). The levels of serum NTx, serum BSP and serum PSA were detected by ELISA. Results: The levels of serum NTx and serum BSP in patients with bone metastasis were 25.38±11.13 nmol/l and 46.28±15.29 ng/ml respectively,which was significantly higher than in those without bone metastasis (12.41±7.04 nmol/l and 26.95±14.49 ng/ml respectively) ( P < 0.05) , There were no significant differences in serum PSA of the two groups (128.46±28.67 ng/ml and 105.23±20.04 ng/ml respectively P >0.05). The sensitivity and specificity of serum NTx in the diagnosis of bone metastasis were 90.0% and 68.6% , respectively; the sensitivity and specificity of serum BSP were 84.2% and 71.4%, respectively; the sensitivity and specificity of serum PSA were 81.6% and37.1%. Conclusion: The levels of serum NTx and BSP were important biomarkers for diagnosis of bone metastasis prostate cancer. |