IGF-1在宫颈鳞状细胞癌中的表达及预后分析-现代医学

IGF-1在宫颈鳞状细胞癌中的表达及预后分析

单位：尚义县医院妇产科

分类号：

出版年·卷·期（页码）：2013·41·第十一期（800-803）

摘要：

目的：探讨胰岛素样生长因子1（IGF-1）在宫颈鳞状细胞癌组织中的表达及临床病理意义与预后分析。方法：应用免疫组织化学(EnVisionTM)法分别检测慢性宫颈炎25例、宫颈上皮内瘤变35例及宫颈鳞状细胞癌75例组织中IGF-1的表达情况。结果：IGF-1 表达阳性率在慢性宫颈炎组织中为3.33%，宫颈上皮内瘤变组织中为37.14%，宫颈鳞状细胞癌组织中为57.33%，三组之间差异有统计学意义（χ2=26.13，P<0.01）。在宫颈鳞状细胞癌相关临床病理因素中，IGF-1的表达与肿瘤大小、淋巴结转移、远处脏器转移、FIGO分期有关，差异均有统计学意义（P<0.05），但与年龄、组织学类型、增值指数（Ki-67）、P53无关，差异无统计学意义（P>0.05）。生存分析显示，IGF-1蛋白阳性患者生存率明显低于阴性患者，差异有统计学意义（χ2=4.42，P<0.05）。结论：在不同的宫颈病变中，IGF-1的表达随着病变的升级而逐步升高，这表明IGF-1在一定程度上参与了宫颈病变的演变，同时也预示着患者预后差。

Objective: To investigate the expression of IGF-1 in cervical squamous-celled carcinoma and clinicopathological significance and prognosis. Methods: The expression of IGF-1 was detected by immunohistochemisty(Enlivion TM) in chronic cervicitis with 25 cases 、cervical intraepithelial neoplasia with 35 cases and cervical squamous-celled carcinoma with75 cases. Results: The expression rate of IGF-1protein in chronic cervicitis 、cervical intraepithelial neoplasia and cervical squamous-celled carcinoma was respectively 3.33%、37.14%、57.33%，there was statistically significant among them（χ2=26.13，P<0.01）. In cervical squamous-celled carcinoma related clinicopathological factors, the expression of IGF-1was related to tumor size、lymph node metastasis、distant place organ metastasis and FIGO Staging（P<0.05）,but not to age 、histological type、Ki-67 and P53（P>0.05）; Survival analysis showed that the survival rate of positive IGF-1 was obviously less than negative IGF-1（χ2=4.42，P<0.05）. Conclusions: In cervix morbid change, the expression of IGF-1 were escalated along with morbid change upgrade, which indicated that IGF-1 took part in the development of cervix morbid change, meanwhile, the patients prognosis was poor.

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