Objective: To investigate whether a continuous infusion of low dose esmolol results in an opioid-sparing effect during laparoscopic gynecologic surgery. Methods: 56 patients received the laparoscopic gynecologic surgery in our hospital from September 2011 to May 2012. They were randomly divided into saline group and esmolol group, and their duration of anesthesia and surgery, degreed of pain, total anmount of fentanyl used in PACU and time to discharge from the PACU were recorded. Fisher’s Exact test was used to compare ASA physical status, frequency of postoperative nausea and vomiting (PONV), and frequency of administered rescue analgesics and anti-emetics. The before effect-site concentration of remifentanil between the two groups was compared by Student’s t-test. The after effect-concentration of remifentanil by infusion of study drugs was analyzed by repeated-measures analysis of variance. Results: The before-concentration of remifentanil was not statistically significantly different between the two groups (P>0.05). In the esmolol group, the effect-site concentration of remifentanil was significantly decreased following the esmolol infusion (33.3% decrease, from 2.7 to 1.8 ng/ mL; P<0.005). The total dose of remifentanil was also lower in the esmolol group. Conclusions: The esmolol group had qualitatively better results for NRS for the degree of pain and the required amount of rescue analgesic in the PACU.