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高脂血症患者血清粘附分子,超敏C反应蛋白,同型半胱氨酸的检测及临床意义
作者:徐鑫  
单位:中国医科大学附属盛京医院
关键词:高脂血症 粘附分子 同型半胱氨酸 超敏C反应蛋白 
分类号:
出版年·卷·期(页码):2014··第一期(0-)
摘要:

目的:探讨高脂血症患者细胞间粘附分子-1(ICAM-1),血管细胞粘附分子-1(VCAM-1),同型半胱氨酸(Hcy),超敏C反应蛋白(hs-CRP),E-选择素与低密度脂蛋白胆固醇(LDL-C),甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C)的相互关系及临床意义。方法:测112例患者和62例健康体检者血清中胆固醇(TC)、LDL-C、TG、HDL-C、ICAM-1、VCAM-1、Hcy、hs-CRP、E-选择素的水平。结果:高胆固醇血症患者血清E-选择素、VCAM-1、VCAM-1、Hcy、hs-CRP明显高于健康对照组和高甘油三酯血症患者,差别具有统计学意义(P<0.001);与健康对照组相比,高甘油三酯血症患者E-选择素、VCAM-1、VCAM-1、Hcy升高并不明显,差别不具有统计学意义(P>0.05),但是hs-CRP明显高于健康对照组,差别具有统计学意义(P<0.05)。相关分析表明:LDL-C与Hcy、E选择素、VCAM-1、ICAM-1、 hs-CRP存在相关关系;HDL-C与Hcy、E选择素、VCAM-1、ICAM-1存在负性相关关系;TG与Hcy、E选择素、VCAM-1、ICAM-1、 hs-CRP不存在相关关系。结论:与高甘油三酯血症患者和健康对照组相比,高胆固醇血症患者Hcy、E选择素、VCAM-1、ICAM-1、 hs-CR的升高更容易罹患心血管疾病。

Objective:To analyze the relationship among cell adhesion facator、high sensitivity C-reactive protein、homocysteinein and low density lipoprotein cholesterol、high density lipoprotein cholesterol、triglycerides.Methods: We determined TC、LDL-C、TG、HDL-C、ICAM-1、VCAM-1、Hcy、hs-CRP、E-selection levels of 112 patients and 62 control group.Results :ICAM-1、VCAM-1、Hcy、hs-CRP、E-selection levels with hypercholesterlemia were statistically significantly higher than the hypertriglyceridemia (P<0.001)and control group(P<0.001);Comparison of subjects with hypertriglyceridemia with the subjects in the control group did not yield a significance difference in terms of ICAM-1、VCAM-1、Hcy、E-selection,but hs-CRP value was higher(P<0.001).Pearson's correlation analysis revealed that LDL-C levels were correlated with ICAM-1、VCAM-1、Hcy、hs-CRP、E-selection in the whole study group;TG levels were not correlated with ICAM-1、VCAM-1、Hcy、E-selection;HDL-C levels were a negative correlation with ICAM-1、VCAM-1、Hcy、hs-CRP、E-selection.Conclusion:The increase of Hcy、E-selection、VCAM-1、ICAM-1、 hs-CRP in hypercholesterlemia reflects their high cardiovascular risk,compared with hypertriglyceridemiaand the control group.

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