Objecttive To evaluate the relationship between Hypoxia-inducible factor-1ɑ in placenta and preeclampsia. Methods Through the term of Hypoxia-inducible factor-1ɑ and Preeclampsia to searching a case-control study in which some cases about the relationship between Hypoxia-inducible factor-1ɑ in placenta and preeclampsia were searched out from Mesline, EMBase, Pubmed, Google, CBMdisc , wangfang darabase to have the sifted, evaluated and extracted for meta-analysia. Results The author evaluated the six articles being involved in the case-control study finally from three aspects: the selection nethods of case and control group used, comparability of the two groups, contact exposure assessment method. Meta-analysis indicated that there were statistical significance between Hypoxia-inducible factor-1ɑ in placenta and Preeclampsia [OR=5.65, 95%CI(3.42, 9.33)]. Conclusion There is significant correlation between Hypoxia-inducible factor-1ɑ in placenta and development of Preeclampsia. |