Objective: To compare the impact on vascular remodeling of four different hypertension-lowering drugs based on effective hypertension-control among out-door patients. Methods: Two hundred hypertensive patients were divided into four groups treated with ACEI, ARB, CCB or β-blockers respectively (n=50 in each group). 50 subjects were enrolled as controls. 24-hour blood pressure monitor, carotid IMT, PWV, radial artery wall/luminal ratio, CRP were collected and analyzed among five groups. Results: Average IMT, PWV, radial artery wall/luminal ratio and CRP in hypertensive patients were higher than that in controls, and decreased significantly after effective treatment (all P<0.05), without difference among four hypertensive groups (P>0.05). Conclusion: Hypertensive patients had higher values of average IMT, PWV, radial artery wall/luminal ratio and CRP compared with that in controls and the markers of vascular remodeling showed improvement after effective hypertension-therapy. |