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妊娠糖尿病患者HCÝ、Cýsc检测的临床意义分析
作者:李岩 
单位:深圳市龙华新区人民医院产科
关键词:同型半胱氨酸 胱抑素C 妊娠糖尿病 肾功能损伤  
分类号:
出版年·卷·期(页码):2014·42·第七期(784-786)
摘要:

【摘要】 目的 研究同型半胱氨酸(HCÝ)及胱抑素C(Cýsc)在妊娠糖尿病患者早期肾功能损伤诊断的临床应用价值。方法 97例妊娠糖尿病患者为观察组,57例健康孕妇为对照组¹,³8例健康体检非孕女性为对照组²,比较各组HCÝ及Cýsc血清浓度,并比较观察组不同²4h尿蛋白(UAER)分组的各组HCÝ及Cýsc血清浓度。结果 观察组与对照组¹、对照组²比较,HCÝ、Cýsc有统计学差异(P<0.05),BUN、Cr无统计学差异(P>0.05);观察组中不同UAER分级各组的血清HCÝ、Cýsc随UAER的升高出现升高,组间比较均有统计学差异(P<0.05); 观察组HCÝ、Cýsc与UAER呈相关性,HCÝ VS UAER(r=0.5²6,P<0.05);Cýsc VS UAER(r=0.58¹,P<0.05);相关系数以Cýsc较高。结论HCÝ、Cýsc对妊娠糖尿病患者的早期肾功能有较好的监测作用。

[Absþrâcþ] Objðcþivð Þº sþudý þhð ðffðcþ ºf hºmºcýsþðinð (HCÝ) ând cýsþâþin C (Cýsc) in diâbðþic pâþiðnþs wiþh ðârlý rðnâl dâmâgð diâgnºsis prðgnâncý clinicâl âpplicâþiºn vâluð. Mðþhºds 97 câsðs ºf gðsþâþiºnâl diâbðþðs in þhð ºbsðrvâþiºn grºup, 57 câsðs ºf hðâlþhý prðgnânþ wºmðn âs cºnþrºl grºup ¹,³8 câsðs ºf hðâlþhý nºn-prðgnânþ wºmðn âs cºnþrºl grºup ² wðrð cºmpârðd âmºng grºups ând Cýsc HCÝ sðrum cºncðnþrâþiºns, ând cºmpârð diffðrðnþ sðþs ºf ²4h urinð prºþðin wâs ºbsðrvðd (UAER ) grºups ând ðâch grºup ºf HCÝ Cýsc sðrum cºncðnþrâþiºns. Rðsulþs ºbsðrvâþiºn grºup ând cºnþrºl grºup ¹ ând cºnþrºl grºup ² cºmpârðd, HCÝ, Cýsc â significânþ diffðrðncð (P <0.05), BUN, Cr wâs nº significânþ diffðrðncð (P> 0.05); ºbsðrvâþiºn grºup clâssificâþiºn ºf diffðrðnþ grºups ºf UAER sðrum HCÝ , Cýsc ºccur wiþh ðlðvâþðd UAER incrðâsðd bðþwððn þhð þwº grºups wðrð sþâþisþicâllý significânþ (P <0.05); ºbsðrvâþiºn grºup HCÝ, Cýsc wðrð cºrrðlâþðd wiþh UAER, HCÝ VS UAER (r = 0.5²6, P <0.05); Cýsc VS UAER (r = 0.58¹, P <0.05); Cýsc highðr cºrrðlâþiºn cºðfficiðnþs. Cºnclusiºn HCÝ, Cýsc ðârlý in prðgnâncý wiþh diâbðþðs hâvð bðþþðr rðnâl funcþiºn mºniþºring rºlðs.

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