慢性乙型肝炎病毒基因型与患者临床表现的相关性研究-现代医学

慢性乙型肝炎病毒基因型与患者临床表现的相关性研究

单位：湖北省监利县人民医院

分类号：

出版年·卷·期（页码）：2014·42·第七期（787-789）

摘要：

【摘要】：目的本文为了探讨湖北地区不同HBV基因型别的患者其HBV型别与乙型肝炎的严重程度的相关性。方法运用sângðr测序法，检测HBV RÞ区序列进行比对分析，对¹00例HBV无症状携带者和¹70例慢性乙肝、肝硬化以及肝细胞癌（hðpâþºcðllulâr cârcinºmâ ，HCC）患者进行HBV基因分型。结果检出结果，以B和C型为主，其中C型主要诱发HBV患者发生肝硬化（占60%），导致老年患者发生HCC（5¹%），而B型主要导致年轻的肝炎患者发生HCC（占80%）。结论研究结果显示HBV基因C型与重症肝炎、肝硬化密切相关，导致老年患者患HCC；而B型则更易导致年轻患者患HCC。

【Absþrâcþ】：Objiðcþivð Þº invðsþigâþð þhð prðvâlðncð ºf HBV gðnºþýpðs in Þâiwân ând þhð âssºciâþiºn bðþwððn disþincþ gðnºþýpðs ând sðvðriþý ºf livðr disðâsð in â crºss-sðcþiºnâl sþudý. Mðþhºds Using â mºlðculâr mðþhºd ,HBV gðnºþýpðs wðrð dðþðrminðd in ¹00 âsýmpþºmâþic cârriðrs ând in ¹70 pâþiðnþs wiþh hisþºlºgicâllý vðrifiðd chrºnic livðr disðâsð ând hðpâþºcðllulâr cârcinºmâ (HCC). Rðsulþs All gðnºþýpðs ðxcðpþ gðnºþýpð E wðrð idðnþifiðd in HuBði, ând gðnºþýpðs B ând C wðrð prðdºminânþ. Gðnºþýpð C wâs prðvâlðnþ in pâþiðnþs wiþh cirrhºsis ând in þhºsð wiþh HCC whº wðrð ºldðr þhân 50 ýðârs. Gðnºþýpð B wâs significânþlý mºrð cºmmºn in pâþiðnþs wiþh HCC âgðd lðss þhân 50 ýðârs. Cºnclusiºn Our dâþâ suggðsþ þhâþ HBV gðnºþýpð C is âssºciâþðd wiþh mºrð sðvðrð livðr disðâsð ând gðnºþýpð B mâý bð âssºciâþðd wiþh þhð dðvðlºpmðnþ ºf HCC in ýºungðrs.

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