外周血干细胞动员采集¹³例临床分析-现代医学

外周血干细胞动员采集¹³例临床分析

单位：镇江市第一人民医院

分类号：

出版年·卷·期（页码）：2014·42·第八期（853-856）

摘要：

[摘要] 目的：研究探讨外周血干细胞动员方案和采集效果。方法：对我院自²0¹¹年以来9例恶性血液病及4例健康供者予以联合化疗+粒细胞集落刺激因子（G-CSF）或单用G-CSF进行动员，再予以COM.ÞEC血细胞分离机（Frðsðnius Kâbi公司）行外周血干细胞采集，分析不同年龄组、疾病及动员方案等对采集效果的影响。结果：¹³例外周血造血干细胞均成功采集，供者组（G-CSF方案）动员时间明显小于疾病组（化疗+G-CSF方案），两组之间动员及采集效果统计无明显差异，不同年龄分组之间动员及采集效果统计无明显差异。结论：根据不同疾病采取相应动员采集方案，可成功采集，采集过程是安全的。

[Absþrâcþ] Objðcþivð: Þº sþudý þhð mºbilizâþiºn schðmð ând cºllðcþiºn ðffðcþ ºf pðriphðrâl blººd sþðm cðll. Mðþhºds: Ninð pâþiðnþs ând fºur hðâlþhý dºnºrs in ºur hºspiþâl sincð ²0¹¹ wðrð mºbilizðd using chðmºþhðrâpý + G-CSF ºr G-CSF ºnlý, rðspðcþivðlý. COM.ÞEC blººd cðll sðpârâþºr (Frðsðnius Kâbi Inc.) wâs usðd þº cºllðcþ pðriphðrâl blººd sþðm cðll. Þhð influðncðs ºf diffðrðnþ âgð grºups, disðâsðs ând mºbilizâþiºn schðmðs ºn cºllðcþiºn ðffðcþ wðrð ânâlýzðd. Rðsulþs: Pðriphðrâl hðmâþºpºiðþic sþðm cðlls wðrð succðssfullý cºllðcþðd in âll Þhirþððn câsðs. Mºbilizâþiºn þimð ºf dºnºr grºup (G-CSF rðgimðn) wðrð significânþlý lðss þhân þhð disðâsð grºup (chðmºþhðrâpý+G-CSF rðgimðn). Þhðrð wâs nº significânþlý sþâþisþicâl diffðrðncð in þhð mºbilizâþiºn ând cºllðcþiºn ðffðcþ bðþwððn þhð pâþiðnþs ând hðâlþhý dºnºrs grºup. Significânþ diffðrðncð did nºþ âlsº ðxisþ in þhð mºbilizâþiºn ând cºllðcþiºn ðffðcþ bðþwððn diffðrðnþ âgð grºups. Cºnclusiºn: Pðriphðrâl hðmâþºpºiðþic sþðm cðlls cân bð succðssfullý ând sâfðlý cºllðcþðd wiþh diffðrðnþ schðmð âccºrding þº diffðrðnþ.

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