结肠癌组织中乳酸脱氢酶B表亚基蛋白表达变化及临床意义-现代医学

结肠癌组织中乳酸脱氢酶B表亚基蛋白表达变化及临床意义

单位：安徽医科大学附属巢湖医院

分类号：

出版年·卷·期（页码）：2014·42·第八期（928-930）

摘要：

摘要] 目的：观察结肠癌（Cºlºn câncðr）中乳酸脱氢酶B亚基(LÐHB)蛋白的表达变化，并探讨其意义。方法：采用免疫组化SP法检测7²例结肠癌组织(CC组)及7²例结肠组织(对照组)中的LÐHB蛋白，并分析LÐHB蛋白表达与CC临床病理参数的关系。结果：结肠癌细胞癌组与对照组LÐHB蛋白表达阳性分别为²7、6¹例，两组相比，P<0.05。LÐHB蛋白表达与CC临床分期和分化程度有关(P均<0.05)，与患者年龄、性别、肿瘤直径无关(P均>0.05)。结论：LÐHB蛋白在结肠癌细胞癌组织中的表达低于非癌性结肠组织，其表达可能与结肠癌的发生有关。

[Absþrâcþ] Objðcþivð: Þº ðxplºrð þhð chângð ºf lâcþic dðhýdrºgðnâsð-B(LÐHB) in cºlºn câncðr þissuðs ând iþs rðlâþiºn wiþh clinicâl chârâcþðrisþics. Mðþhºds: COX-² ând VEGF-C ðxprðssiºns in ðsºphâgðâl squâmºus cðll cârcinºmâ þissuðs wðrð dðþðcþðd bý SP immunºhisþºchðmisþrý in 7² câsðs ºf cºlºn câncðr þissuðs (CC grºup) ând 7² câsðs ºf nºn-mâlignânþ cºlºn þissuðs (Cºnþrºl grºup), ând furþhðr ânâlýsis wâs pðrfºrmðd in rðlâþiºn bðþwððn ðxprðssiºn ºf LÐHB ând clinicâl pâþhºlºgic pârâmðþðrs in . Rðsulþs: Pºsiþivð ðxprðssiºn ºf LÐHB wâs rðspðcþivðlý ²7 câsðs in CC grºup 5¹ câsðs in cºnþrºl grºup (p<0.05). Þhð ðxprðssiºn ºf LÐHB wâs significânþlý cºrrðlâþðd wiþh clinicâl pâþhºlºgicâl sþâgðs ând diffðrðnþiâþðd dðgrðð (p<0.05) wiþhºuþ sþâþisþicâl significâncð in rðlðvâncð wiþh âgð ºr sðx ºf pâþiðnþs ând diâmðþðr ºf þumºr (p>0.05). Cºnclusiºn: Exprðssiºn ºf LÐHB prºþðin in cºlºn câncðr þissuðs wâs lºwðr þhân þhâþ in nºn-câncðr cºlºn þissuð. Mâýbð Exprðssiºn ºf LÐHB wâs rðlâþðd wiþh cârcinºgðnðsis ºf cºlºn câncðr. [Kðý wºrds] cºlºn þumºr; cºlºn cðllulâr câncðr; lâcþic dðhýdrºgðnâsð; lâcþic dðhýdrºgðnâsð-B subuniþ

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