长期应用小剂量辛伐他汀治疗高血脂症的观察-现代医学

长期应用小剂量辛伐他汀治疗高血脂症的观察

单位：西安交通大学医院

分类号：

出版年·卷·期（页码）：2014··第十一期（0-）

摘要：

目的：尝试长期服用国产小剂量辛伐他汀，结合调整投药方法来进行调脂干预，观察该方法的有效性、安全性。方法：选取我院愿意接受本治疗的脂质全部、或其中某一单项增高的31例患者，给予辛伐他汀 10mg/日，晚一次顿服，每月服20天，停10天，循环往复，持续服药疗程3—24个月，观察治疗前后血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL-C）、肌酸激酶（CK）、谷草转氨酶（ALT）的变化。结果：治疗后TC、TG、LDL-C等指标较治疗前有下降，差异有统计学意义（P 均＜0.05），谷草转氨酶（ALT）与CK治疗前后无改变，差异无统计学意义（P 均＞0.05）。结论：国产小剂量辛伐他汀、调整投药方式后，在一定程度达标的前提下，达到了长期调脂的目的，兼顾了效益—费用—风险，且服药依从性良好。

AbstractAim：To observe the safety and efficacy of low dosage of generic simvastatin on long term management of high cholesterols. Method: All patients in this study were diagnosed with high cholesterols and agreed to participate in this study. Simvastatin was given in 10 mg/day before bedtime for consecutive 20 days, and then stopped for 10 days before retaking simvastatin again. Lipid panel including total cholesterols (TC), triglyceride (TG) and LDL-C was monitored before and during the treatment. Serum levels of creatine kinase (CK) and ALT were monitored for liver function and myopathy. Results: Cholesterol levels in all patients were significantly reduced after enrolled for 90-720 days (P<0.05), while CK and ALT were not significantly elevated (P>0.05). Conclusion: Low dosage of generic simvastatin is safe and effective on long term management of high cholesterols. The rejimentation is safe, cost-effective and easy to comply.

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