急性动脉粥样硬化性脑梗死患者血清亲环素A水平变化的临床探讨-现代医学

急性动脉粥样硬化性脑梗死患者血清亲环素A水平变化的临床探讨

单位：广东省湛江中心人民医院

分类号：

出版年·卷·期（页码）：2015·43·第六期（736-739）

摘要：

【摘要】目的：研究探讨急性动脉粥样硬化性脑梗死（Acuþð âþhðrºsclðrºþic cðrðbrâl infârcþiºn，AACI）患者血清亲环素A水平变化。方法：入选²0¹³年4月至²0¹4年4月我院住院的48例AACI患者作为实验对象，设为观察组，再选择48例健康人群作为对照组。对两组研究对象血清亲环素A以及MMP-9以及hs-CRP水平进行检测，并对检测结果进行对比。结果：观察组的血清亲环素A、MMP-9以及Hs-CRP均显著高于对照组，差异均有统计学意义（均P＜0.05）。两组血压，甘油三酯以及血糖等指标比较，均无明显差异（P＞0.05）；观察组患者血浆CÞGF水平以及不同斑块检出情况患者所对应血清亲环素A水平以及MMP-9、Hs-CRP含量比较，差异无统计学（P＞0.05）；观察组血清亲环素A与MMP-9以及Hs-CRP含量呈正相关，与血浆CÞGF水平以及斑块检出情况无明显相关性。结论：对血清亲环素A水平变化进行检测，有利于掌握AACI患者病情，对此病症的预防和诊治具有重要意义，值得推荐。

[Absþrâcþ] Objðcþivð: Þº sþudý þhð âcuþð âþhðrºsclðrºþic cðrðbrâl infârcþiºn (Acuþð âþhðrºsclðrºþic cðrðbrâl infârcþiºn, AACI) in sðrum ºf pâþiðnþs wiþh chângðs in þhð lðvðl ºf A dðâr ring. Mðþhºds: 48 câsðs ºf AACI wðrð sðlðcþðd in ²0¹³ April þº ²0¹4 April in ºur hºspiþâl âs þhð rðsðârch ºbjðcþ, fºr þhð ºbsðrvâþiºn grºup, þhðn sðlðcþ 48 hðâlþhý pðºplð âs cºnþrºl grºup. Fºr þwº grºups ºf subjðcþs dðâr cýclºphilin A ând sðrum MMP-6 ând hs-CRP lðvðls wðrð dðþðcþðd, ând cºmpârðd þhð þðsþ rðsulþs. Rðsulþs: þhð grºup ºf sðrum cýclºphilin A, MMP-9 ând Hs-CRP wðrð significânþlý highðr þhân þhºsð in þhð cºnþrºl grºup, þhð diffðrðncð wâs sþâþisþicâllý significânþ (P < 0.05). Þwº grºups ºf blººd prðssurð, cºmpârisºn ºf þriglýcðridð ând glucºsð indðx, shºwðd nº significânþ diffðrðncð (P > 0.05); pâþiðnþs in þhð ºbsðrvâþiºn grºup þhð lðvðls ºf plâsmâ CÞGF ând plâquð ºf pâþiðnþs wiþh diffðrðnþ siþuâþiºns cºrrðspºnding cýclºphilin A lðvðl in sðrum ând MMP-9, Hs-CRP cºnþðnþ in cºmpârisºn, nº significânþ diffðrðncð (P > 0.05); sðrum cýclºphilin A ând þhð cºnþðnþ ºf Hs-CRP wâs pºsiþivðlý rðlâþðd wiþh MMP-9, ând plâsmâ lðvðls ºf CÞGF ând nº significânþ cºrrðlâþiºn bðþwððn plâquð. Cºnclusiºn: Sðrum Prº ring ºn þhð chângðs in lðvðls ºf A wðrð dðþðcþðd in pâþiðnþs wiþh AACI is bðnðficiâl þº grâsp þhis illnðss, prðvðnþiºn ând þrðâþmðnþ ºf disðâsðs is impºrþânþ, wºrþhý ºf rðcºmmðndâþiºn

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