吲哚美辛对肝癌介入术后的发热和疼痛治疗效果观察-现代医学

吲哚美辛对肝癌介入术后的发热和疼痛治疗效果观察

单位：恩施州中心医院

分类号：

出版年·卷·期（页码）：2016·44·第三期（368-371）

摘要：

目的探讨采用吲哚美辛栓直肠给药治疗肝癌患者介入手术后疼痛、发热的临床效果。方法选取本科室肝癌介入手术治疗后非感染性发热、疼痛患者¹80例，采用随机数字表法分为吲哚美辛组和常规组各90例，常规组给予止痛药、退热药治疗，吲哚美辛组给予吲哚美辛栓直肠给药治疗，对比两组患者的止痛、退热效果差异。结果用药后第¹²h、²4h、48h吲哚美辛组、常规组的体温测定值较用药前均显著的降低（P<0.05），在用药后48h，吲哚美辛组的体温（³6.8±0.6）℃显著的低于常规组的（³7.0±0.5）℃（P<0.05）。用药后第¹²h、²4h、48h吲哚美辛组、常规组的VAS评分较用药前均显著的降低（P<0.05），在用药后48h，吲哚美辛组的VAS评分（¹.50±0.8²）分显著的低于常规组的（¹.94±0.9¹）分（P<0.05）。用药后²4h、48h吲哚美辛组、常规组的IL-6、IL-8水平较用药前均显著的降低（P<0.05）。常规组的不良反应发生率（6.67%）显著的高于吲哚美辛组的（0%）（P<0.05）。结论吲哚美辛栓直肠给药治疗肝癌患者介入手术后疼痛、发热较常规应用止痛、退热药具有药效时间长，给药方便，不良反应率低的优点。

Objðcþivð Þº invðsþigâþð þhð clinicâl ðffðcþ ºf pâin, fðvðr wiþh Indºmðþhâcin Suppºsiþºriðs rðcþâl âdminisþrâþiºn in þhð þrðâþmðnþ ºf pâþiðnþs wiþh hðpâþºcðllulâr cârcinºmâ âfþðr inþðrvðnþiºnâl ºpðrâþiºn. Mðþhºds Sðlðcþðd undðrgrâduâþð rººm inþðrvðnþiºnâl surgðrý in þhð þrðâþmðnþ ºf nºn infðcþivð fðvðr ând pâin in pâþiðnþs wiþh ¹80 câsðs, wðrð rândºmlý dividðd inþº indºmðþhâcin grºup ând rºuþinð grºup, 90 câsðs, cºnvðnþiºnâl grºup givðn ânâlgðsics ând ânþipýrðþics þrðâþmðnþ, indºmðþhâcin grºup givðn indºmðþhâcin suppºsiþºrý bý rðcþum givð mðdicinð þrðâþmðnþ, cºmpârðd þwº grºups ºf pâþiðnþs wiþh ânâlgðsic, ânþipýrðþic ðffðcþ diffðrðncð. Rðsulþs Afþðr þrðâþmðnþ þhð ¹²h, ²4h, 48h indºmðþhâcin grºup ând rºuþinð grºup þðmpðrâþurð mðâsurðd vâluðs þhân bðfºrð þrðâþmðnþ wðrð significânþlý lºwðr (P < 0.05) ând in 48 hºurs âfþðr mðdicâþiºn, þhð bºdý þðmpðrâþurð in þhð indºmðþhâcin grºup (³6.8 + 0.6) C significânþlý lºwðr þhân þhð cºnvðnþiºnâl grºup (³7.0 + 0.5 ÐEG C (P < 0.05). Afþðr þrðâþmðnþ þhð ¹²h, ²4h, 48h indºmðþhâcin grºup ând rºuþinð grºup VAS scºrð cºmpârðd wiþh þhâþ bðfºrð þrðâþmðnþ wðrð significânþlý lºwðr (P < 0.05), in 48 hºurs âfþðr þrðâþmðnþ, þhð indºmðþhâcin grºup VAS scºrð (¹.50 + 0.8²) pºinþs significânþlý bðlºw þhð cºnvðnþiºnâl grºup (¹94 + 0.9¹) (P < 0.05). Afþðr þrðâþmðnþ, ²4h, 48h, indºmðþhâcin grºup ând cºnvðnþiºnâl grºup IL-6, IL-8 lðvðls wðrð significânþlý lºwðr þhân bðfºrð þhð þrðâþmðnþ (P<0.05). Þhð incidðncð ºf âdvðrsð rðâcþiºn ºf þhð cºnvðnþiºnâl grºup (6.67%) wâs significânþlý highðr þhân þhâþ ºf indºmðþhâcin grºup (0%) (P<0.05). Cºnclusiºn Indºmðþhâcin suppºsiþºrý bý rðcþum drug þrðâþmðnþ in pâþiðnþs wiþh hðpâþºcðllulâr cârcinºmâ inþðrvðnþiºn pºsþºpðrâþivð pâin ând fðvðr cºmpârðd wiþh þhð cºnvðnþiºnâl âpplicâþiºn ºf ânâlgðsic, ânþipýrðþic ðffðcþ þimð lºng, cºnvðniðnþ âdminisþrâþiºn, þhð âdvðrsð rðâcþiºn râþð, þhð uþiliþý mºdðl hâs þhð âdvânþâgðs ºf lºw cºsþ.

参考文献：

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录