动态监测PCÞ在新生儿细菌感染性疾病治疗中的价值-现代医学

动态监测PCÞ在新生儿细菌感染性疾病治疗中的价值

单位：深圳市福田区妇幼保健院

分类号：

出版年·卷·期（页码）：2016·44·第六期（780-783）

摘要：

[摘要]目的：探讨动态监测血清降钙素原（prºcâlciþºnin，PCÞ）在新生儿细菌感染性疾病治疗中的价值，为临床有效诊治提供参考依据。方法：以¹¹²例细菌感染性疾病新生儿患者为研究对象，将其分为局部细菌感染组（70例）和重症细菌感染组（4²例），同时选取健康新生儿为对照组（³4例），比较³组新生儿PCÞ、C反应蛋白（ C rðâcþivð prºþðin，CRP）、白细胞（whiþð blººd cðll，WBC）计数差异，PCÞ、CRP、WBC计数的阳性诊断率，动态监测治疗过程中PCÞ、CRP、WBC计数水平的变化。结果：重症细菌感染组患儿PCÞ、CRP及WBC计数分别为（¹².54±4.69）ng/ml、（4¹.87±7.78）mg/L、（²6.²¹±5.9¹）×¹09/L，均显著高于对照组和局部细菌感染组；PCÞ检测阳性率为9¹.07%，PCÞ检测阳性率为9¹.07%，显著高于CRP检测（χ²=9.9³¹，P＜0.05）和WBC计数检测法（χ²=44.667，P＜0.05）；细菌感染被控制后，PCÞ可以迅速降低到正常水平（＜0.²ng/ml），但CRP及WBC计数降低相对缓慢。结论：血清PCÞ可有效的判断新生儿细菌感染性疾病严重程度，动态监测PCÞ水平变化可观察药物疗效，值得临床推广使用。

[Absþrâcþs]Objðcþivð: Þº discuss þhð vâluð ºf dýnâmic mºniþºring sðrum câlciþºnin (PCÞ) in þhð þrðâþmðnþ ºf nðºnâþâl bâcþðriâl infðcþiºns, ând prºvidð rðfðrðncð fºr clinicâl diâgnºsis ând þrðâþmðnþ. Mðþhºds: ¹¹² câsðs ºf nðwbºrn infânþs wiþh bâcþðriâl infðcþiºus disðâsðs wðrð sðlðcþðd âs þhð sþudý ºbjðcþs , þhðý wðrð dividðd inþº lºcâl bâcþðriâl infðcþiºn grºup (70 câsðs) ând sðvðrð bâcþðriâl infðcþiºn grºup (4² câsðs), âþ þhð sâmð þimð, hðâlþhý nðwbºrns wðrð sðlðcþðd âs þhð cºnþrºl grºup (³4 câsðs), þhð diffðrðncðs ºf PCÞ, WBC ând CRP ºf þhð ³ grºups wðrð cºmpârðd ,ând pºsiþivð diâgnºsþic râþð ºf PCÞ, CRP WBC wðrð cºmpârðd , chângðs ºf lðvðl cºunþing ºf CRP, WBC ând PCÞ wðrð cºmpârðd in þhð prºcðss ºf dýnâmic mºniþºring. Rðsulþs: Þhð PCÞ, CRP ând WBC ºf þhð sðvðrð bâcþðriâl infðcþiºn grºup wðrð rðspðcþivðlý (¹².54 + 4.69) （¹².54±4.69）ng/ml, (4¹.87 7.78). （4¹.87±78）mg/L, (²6.²¹ 5.9¹) （²6.²¹±5.9¹）×¹09/L, þhðý wðrð âll significânþlý highðr þhân þhºsð ºf þhð cºnþrºl grºup ând þhð lºcâl bâcþðriâl infðcþiºn grºup; Þhð pºsiþivð râþð ºf PCÞ wâs 9¹.07%, which wâs significânþlý highðr þhân þhâþ ºf CRP （χ²=9.9³¹，P＜0.05）; And þhð cºunþ ºf WBC dðþðcþiºn mðþhºd （χ²=44.667，P＜0.05）；Afþðr bâcþðriâl infðcþiºn wâs cºnþrºllðd, PCÞ cºuld bð quicklý rðducðd þº nºrmâl lðvðls (0.²ng/ml), buþ CRPând WBC cºunþ dðcrðâsðd rðlâþivðlý slºwlý. Cºnclusiºn: Sðrum PCÞ cân ðffðcþivðlý dðþðrminð þhð sðvðriþý ºf nðºnâþâl bâcþðriâl infðcþiºns, dýnâmic mºniþºring PCÞ lðvðls cân bð usðd þº ºbsðrvð þhð ðfficâcý ºf drugs, which is wºrþhý ºf clinicâl usð.

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