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肾功能不全对老年慢性心力衰竭患者病死率和心衰再次住院率等预后影响
作者:王文君  
单位:北京市第六医院
关键词:肾功能不全 慢性心力衰竭 预后因素 
分类号:
出版年·卷·期(页码):2016··第七期(0-)
摘要:

[摘要]目的 探究老年慢性心力衰竭(CHF)合并肾功能不全患者的临床特征,并分析肾功能不全对患者预后的影响。方法 回顾性分析2011年1月—2013年1月北京第六医院心内科收治的136例老年CHF患者的一般资料,根据患者的肾小球滤过率(GFR)估算的肾功能情况将患者分成肾功能正常或轻度损伤组和肾功能不全组,分析两组患者的相关资料;观察入院后2年内患者因病死亡率、因心衰再次入院等预后情况,并通过Logistic回归分析肾功能不全与其的。结果 两组在性别、年龄、NYHA分级和病因等一般资料上相比,差异无显著性意义(p>0.05),可行组间对比;临床症状相比,夜间阵发性呼困、劳力性呼困和下肢浮肿的出现率更高(p<0.05);实验室指标与心功能检查相比,Hb、RBC、LVEF、GFR更低,CRP、TG、GLU、BNP、NT-proBNP更高(p<0.05);预后结果相比,因心衰再次入院及病死率均更高(p<0.05);Logistic回归分析显示,肾功能不全是影响患者病死率和因心衰再次入院率的独立预后因素。结论 肾功能不全的CHF老年患者临床特征异于肾功能轻度受损或正常的CHF患者,肾功能不全是影响患者病死率和因心衰再次入院率的独立预后因素。

[Summary] Objective To investigate the clinical feature of chronic heart failure(CHF)in the elderly with renal dysfunction,and analyze the effect of renal dysfunction on patients after the treatment. Methods The data of 136 CHF patients who were admitted to the Department of Cardiology in Six Hospital of Beijing between 2011.1 to 2013.1..According to eGFR,evaluate patients’ renal function and divided patients into two group:the renal dysfunction group and the normal renal function or mild renal function damage group.Analyze patients’ clinical data and the mortality and hospitalization rate of repeated heart failure by logistic regression. Result Compared with the normal renal function or mild group general group,the renal dysfunction group is older, NYHA classification grade II and larger proportion of smaller percentage of Ⅳ grade, etiology coronary heart disease, heart disease share a greater proportion of diabetic complications aspect, lung infections and OMI greater proportion (p <0.05); compared with clinical symptoms, paroxysmal nocturnal respiratory difficulties, difficulties arise rate exertional respiratory and lower limb edema higher (p <0.05); compared with laboratory parameters and cardiac function tests, Hb, RBC, LVEF,GFR less, CRP, TG, GLU,BNP,NT-proBNP higher (p <0.05), compared to Clinical outcome, malignant arrhythmia, due to heart failure readmissions, recurrent coronary events and mortality rates are higher because of illness (p <0.05);By logistic regression analyze,Renal dysfunction was an independent risk factor to mortality and hospitalization rate of repeated heart failure. Conclusion The clinical features of eldly CHF patients with renal dysfunction is different from the normal renal function or mild renal function damage CHF patients.Renal dysfunction was anindependent risk factor to mortality and hospitalization of repeated heart failure.

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