Objective To explore the clinical characteristics and pathogenesis of walk-through angina. Methods The data of walk-through angina diagnosed and treated by Tangshan worker's hospital from 2007 to 2013 was collected to be the experimental group. According to the results of coronary arteriography, they were divided into collateral and collateral-free group, At the same time, 200 patients with atypical angina pectoris were selected to be as the control. Analysis on the coronary artery lesions, proportion of formation of collateral circulation in coronary artery disease and heart attacks before and after elevated levels of HS-CRP and IMA difference in each group . Results Collateral circulation rate in the experimental group was higher than in the control group ; Prior to onset of angina pectoris, cardiac biochemical markers of three groups showed no significant difference in levels of HS-CRP and IMA (P>0.05), After the onset of 3h, group hs-CRP with and without collateral circulation and IMA levels were on average higher than in the control group, and the difference was statistically significant (P<0.05). Conclusions Pathogenesis of angina may be associated with the establishment of collateral circulation and coronary artery spasm. Levels of HS-CRP and IMA can be used to predict the risk of atherosclerosis and coronary artery occlusion.