Objective: To explore the fructose-1, 6-bisphosphatase 1(FBP1) expression in gastric cancer and its predictive value for patients prognosis. Methods:A total of 81 cases of gastric carcinoma patients gastric mucosa tissue samples(gastric cancer tissue) and adjacent non tumor mucosa epithelial tissue(adjacent issue) were collected and the normal gastric mucosa(normal tissue) of 65 patients with benign gastric lesions was selected,the FBP1 protein expression level was detected by immunohistochemistry,FBP1 mRNA expression level was detected by RT-PCR.The clinical pathological data of gastric cancer patients was collected,and the relationship between the expression level of FBP1 and the pathological data of the patients with gastric carcinoma were analysed.Gastric cancer patients were followed up, the relationship between the expression of FBP1 and the survival rate of patients were analysed. Results: Gastric cancer tissue FBP1 protein high expression rate was 27.2%(22/81),cancer adjacent tissues was 56.8%(46/81), normal tissue was 83.1%(54/65), gastric cancer tissues FBP1 protein high expression rate was significantly lower than that in the tumor adjacent tissues and normal tissues(P<0.05),the staining score of FBP1 protein in gastric carcinoma tissue was significantly lower than that in adjacent tissues and normal tissues(P<0.05).FBP1 mRNA relative expression in gastric cancer tissues was(0.294±0.048),cancer adjacent tissues was(0.531±0.067),normal tissue was(0.935±0.098),FBP1 mRNA in gastric cancer tissue relative expression was significantly lower than that in paracancerous tissues and normal tissues(P<0.05).The expression level of FBP1 in gastric cancer was related to tumor diameter, TNM stage, lymph node metastasis,the larger the tumor diameter, the higher the TNM stage, and with lymph node metastasis patients lower FBP1 expression rate was higher(P<0.05).The 3 year cumulative survival rate of FBP1 patients with high expression in gastric cancer was 77.4%, 43.8% in low FBP1 expression patients,the 3 year cumulative survival rate of FBP1 high expression group was significantly higher than that in low expression group(P<0.05). Conclusion: The expression level of FBP1 in gastric carcinoma is significantly decreased,the expression level of FBP1 is relate to tumor size, clinical stage and lymph node metastasis.The higher FBP1 expression, the higher survival rate of patients with gastric cancer, FBP1 can be used as one of the prognosis indicators of prognosis for gastric cancer.
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