布地奈德福莫特罗联合噻托溴铵治疗中重度支气管哮喘的临床研究-现代医学

布地奈德福莫特罗联合噻托溴铵治疗中重度支气管哮喘的临床研究

作者：李薇

单位：深圳市罗湖区人民医院内科, 广东深圳 518000

分类号：R562.25

出版年·卷·期（页码）：2017·36·第三期（354-357）

摘要：

目的：研究中重度支气管哮喘患者应用布地奈德福莫特罗和噻托溴铵治疗的有效性及安全性。方法：将我院收治的98例中重度支气管哮喘患者随机分为两组，各49例，对照组应用布地奈德福莫特罗治疗，研究组联合应用布地奈德福莫特罗和噻托溴铵，比较两组的治疗效果、肺功能改善情况、生活质量变化等。结果：研究组治疗后的哮喘控制测试（ACT）评分显著高于对照组，圣乔治呼吸疾病问卷（SGRO）评分显著低于对照组，差异有统计学意义（P<0.05）；治疗后两组的各项指标均有明显改善，研究组的免疫球蛋白E（IgE）、嗜酸粒细胞计数（EOS）均显著低于对照组，1秒用力肺活量（FEV₁）、用力呼气中期流速（FEF）、最大呼气峰流速（PEF）值均显著高于对照组，差异有统计学意义（P<0.05）；研究组的治愈率、总有效率分别为48.98%、81.63%，与对照组的32.65%、63.27%相比，差异均有统计学意义（P<0.05）。结论：中重度支气管哮喘患者应用布地奈德福莫特罗和噻托溴铵进行治疗，能够较好地控制哮喘发作，缓解临床症状，提高患者的生活质量。

Objective: To study the efficacy and safety of Budesonide and formoterol combined with Tiotropium bromide in the treatment of moderate and severe bronchial asthma.Methods: 98 moderate and severe bronchial asthma patients in our hospital were randomly divided into two groups(n=49),patients in the control group were treated with Budesonide and formoterolt, patients in the study group were treated with Budesonide and formoterol combined with Tiotropium bromide. The treatment effect, improvement of lung function, changes in quality of life between the two groups were compared. Results: After treatment, asthma control test (ACT)score of the study group was significantly higher than that of the control group(P<0.05), St Georges respiratory disease questionnaire (SGRO) score was significantly lower than that of the control group(P<0.05).After treatment, the indicators of the two groups were significantly improved, immunoglobulin E (IgE), eosinophilic granulocyte count (EOS) of the study group were significantly lower than those of the control group, forced vital capacity (FEV1), forced expiratory flow rate (FEF), peak expiratory flow rate (PEF) values were significantly higher than those of the control group(P<0.05).The cure rate and total effective rate of the study group were 48.98% and 81.63% respectively, compared with 32.65% and 63.27% in the control group, there were significant differences(P<0.05). Conclusion: Budesonide and formoterol combined with Tiotropium bromide in the treatment of moderate and severe bronchial asthma, can better control asthma attack, relieve clinical symptoms, improve the quality of life of patients.

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