网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
高同型半胱氨酸对高血压患者心脏重构的影响
作者:朱月红1  陆宁1  戴启明2 
单位:1. 芜湖市第一人民医院 心血管内科, 安徽 芜湖 241000;
2. 东南大学附属中大医院 心内科, 江苏 南京 210009
关键词:同型半胱氨酸 高血压 心脏重构 
分类号:R544.1
出版年·卷·期(页码):2017·36·第九期(1316-1319)
摘要:

目的:探讨高同型半胱氨酸血症对高血压患者心脏重构的影响。方法:选取2016年9月-2017年3月我院就诊高血压患者104例,其中正常同型半胱氨酸组52例、高同型半胱氨酸组52例,记录两组心脏彩超结果,比较两组左心房内径(LA)、左心室舒张末期内径(LVED)、室间隔厚度(IVS)、左心室后壁厚度(LVPW)、左心室质量(LVM)、左室心肌质量指数(LVMI)、右心房内径(RA)值。结果:正常同型半胱氨酸组与高同型半胱氨酸组比较,LA (3.81±0.45 vs 3.57±0.38)、LVED (4.84±0.27 vs 4.68±0.27)、IVS (0.88±0.1 vs 0.82±0.09)、LVPW (0.85±0.09 vs 0.8±0.07)、LVW (163.77±36.88 vs 143.58±32.56)、LVWI (95.54±25.3 vs 83.51±19.64)、RV (2.03±0.2 vs 1.94±0.11),差异均有统计学意义。结论:高同型半胱氨酸血症与高血压患者心脏重构相关。

Objective: To explore the effect of hyperhomocysteine on cadiac remodling in patients with hypertensive. Methods: A total of 104 hypertensive patients admitted in our hospital from 2016-09 to 2017-03 were enrolled and divided into 2 groups:normal-Hcy group and high-Hcy group. LAD, LVDD, IVS, LVPW, RA of patients were measured using echocardiography, then LVM and LVMI was evaluated. Results: Compared to the normal-Hcy group, the high-Hcy group had higher level of LA(3.81±0.45 vs 3.57±0.38), LVED(4.84±0.27 vs 4.68±0.27), IVS (0.88±0.1 vs 0.82±0.09), LVPW(0.85±0.09 vs 0.8±0.07), LVW(163.77±36.88 vs 143.58±32.56), LVWI(95.54±25.3 vs 83.51±19.64), RV(2.03±0.2 vs 1.94±0.11).Conclusion: Blood level of homocysteine was positively related to cardiac remodeling in patients with hypertension.

参考文献:

[1] WU W,GUAN Y,XU K,et al.Plasma homocysteine levels predict the risk of acute cerebral infarction in patients with carotid artery lesions[J].Mol Neurobiol,2016,53(4):2510-2517.
[2] 庄微,蔡晓敏,张启高.高同型半胱氨酸血症与心血管疾病相关性研究进展[J].中华实用诊断与治疗杂志,2014,28(05):433-435.
[3] 迟相林,毕建忠,张道强,等.精准医学、模糊医学与高血压的防治[J].中华高血压杂志,2016,24(3):213-215.
[4] HEINEKE J,MOLKENTIN J D.Regulation of cardiac hypertrophy by intracellular signalling pathways[J].Nat Rev Mol Cell Biol,2006,7(8):589-600.
[5] DRAZNER M H.The progression of hypertensive heart disease[J].Circulation,2011,123(3):327-334.
[6] FOELL D,JUNG B,GERMANN E,et al.Hypertensive heart disease:MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities[J].Eur Radiol,2013,23(2):339-347.
[7] MCCULLY K S.Homocysteine metabolism,atherosclerosis,and diseases of aging[J].Compr Physiol,2015,6(1):471-505.
[8] SAGHEB M M,OSTOVAN M A,SOHRABI Z,et al.Hyperhomocysteinemia and cardiovascular risks in hemodialysis patients[J].Saudi J Kidney Dis Transpl,2010,21(5):863-866.
[9] PENG H Y,MAN C F,XU J,et al.Elevated homocysteine levels and risk of cardiovascular and all-cause mortality:a meta-analysis of prospective studies[J].J Zhejiang Univ Sci B,2015,16(1):78-86.
[10] WOCIAL B,BERENT H,KOSTRUBIEC M,et al.Homocysteine,adrenergic activity and left ventricular mass in patients with essential hypertension[J].Blood Press,2002,11(4):201-205.
[11] MOSHAL K S,METREVELI N,FRANK I,et al.Mitochondrial MMP activation,dysfunction and arrhythmogenesis in hyperhomocysteinemia[J].Curr Vasc Pharmacol,2008,6(2):84-92.
[12] SU G,CAO H,XU S,et al.Left atrial enlargement in the early stage of hypertensive heart disease:a common but ignored condition[J].J Clin Hypertens (Greenwich),2014,16(3):192-197.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 458640 位访问者


 ©《现代医学》编辑部
联系电话:025-83272481;83272479
电子邮件: xdyx@pub.seu.edu.cn

苏ICP备09058541