高同型半胱氨酸对高血压患者心脏重构的影响-现代医学

高同型半胱氨酸对高血压患者心脏重构的影响

单位：1. 芜湖市第一人民医院心血管内科, 安徽芜湖 241000;
2. 东南大学附属中大医院心内科, 江苏南京 210009

分类号：R544.1

出版年·卷·期（页码）：2017·36·第九期（1316-1319）

摘要：

目的：探讨高同型半胱氨酸血症对高血压患者心脏重构的影响。方法：选取2016年9月-2017年3月我院就诊高血压患者104例，其中正常同型半胱氨酸组52例、高同型半胱氨酸组52例，记录两组心脏彩超结果，比较两组左心房内径（LA）、左心室舒张末期内径（LVED）、室间隔厚度（IVS）、左心室后壁厚度（LVPW）、左心室质量（LVM）、左室心肌质量指数（LVMI）、右心房内径（RA）值。结果：正常同型半胱氨酸组与高同型半胱氨酸组比较，LA （3.81±0.45 vs 3.57±0.38）、LVED （4.84±0.27 vs 4.68±0.27）、IVS （0.88±0.1 vs 0.82±0.09）、LVPW （0.85±0.09 vs 0.8±0.07）、LVW （163.77±36.88 vs 143.58±32.56）、LVWI （95.54±25.3 vs 83.51±19.64）、RV （2.03±0.2 vs 1.94±0.11），差异均有统计学意义。结论：高同型半胱氨酸血症与高血压患者心脏重构相关。

Objective: To explore the effect of hyperhomocysteine on cadiac remodling in patients with hypertensive. Methods: A total of 104 hypertensive patients admitted in our hospital from 2016-09 to 2017-03 were enrolled and divided into 2 groups:normal-Hcy group and high-Hcy group. LAD, LVDD, IVS, LVPW, RA of patients were measured using echocardiography, then LVM and LVMI was evaluated. Results: Compared to the normal-Hcy group, the high-Hcy group had higher level of LA(3.81±0.45 vs 3.57±0.38), LVED(4.84±0.27 vs 4.68±0.27), IVS (0.88±0.1 vs 0.82±0.09), LVPW(0.85±0.09 vs 0.8±0.07), LVW(163.77±36.88 vs 143.58±32.56), LVWI(95.54±25.3 vs 83.51±19.64), RV(2.03±0.2 vs 1.94±0.11).Conclusion: Blood level of homocysteine was positively related to cardiac remodeling in patients with hypertension.

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