Objective: To explore the association of total lactic acid bacteria and glucose and lipid metabolism and inflammation index in patients with diabetes mellitus.Methods: 120 patients with diabetes coming to our hospital from February 2012 to February 2015 were selected as experimental group. At the same time, 120 healthy volunteers were selected as control group. Glucose and lipid metabolism index fasting blood glucose(FBG), postprandial two hour blood glucose(P2hBG), glycosylated hemoglobin(HbA1c), triglyceride(TG), total cholesterol(TC), low density lipoprotein(LDL-C), high density lipoprotein(HDL-C) and inflammatory markers C reactive protein(CRP) of two groups' subjects were detected. The copy number of Escherichia coli in feces of subjects was determined. The association of total lactic acid bacteria and glucose and lipid metabolism and inflammation index was calculated.Results: The levels of FBG, HbA1c and P2hBG in the experimental group were significantly higher than those in the control group (P<0.05), and the levels of TG, HDL-C, LDL-C and TC in the experimental group were significantly higher than those in the control group (P<0.05). And patients in the experimental group had higher level of inflammatory factor CRP (P<0.05). In experimental group, the total lactic acid bacillus copy number and Lactobacillus acidophilus, Bulgaria lactobacillus, Rhamnose lactobacillus, Lactobacillus casei copy number were significantly higher than those in the control group (P < 0.05). There was no significant difference between the copy number of Lactobacillus planetarium in the two groups (P>0.05). There was no association between total lactic acid bacteria and glucose metabolism and inflammation index (P>0.05).LDL-C was significantly negatively correlated with the copy number of total lactic acid bacteria (P<0.05). Conclusion: The number of intestinal lactobacilli is significantly changed in diabetic patients. The number of lactic acid bacteria is correlated with blood lipid metabolism. |
[1] BURGESS P I,MACCORMICK I J C,HARDING S P,et al.Epidemiology of diabetic retinopathy and maculopathy in Africa:a systematic review[J].Diabet Med,2013,30(4):399-412.
[2] 聂昕,谯雁彬,陈西嘉,等.糖尿病并发白内障患者手术前后结膜囊菌群分析[J].中华医院感染学杂志,2016,26(5):1064-1066.
[3] POK E H,LEE W J.Gastrointestinal metabolic surgery for the treatment of type 2 diabetes mellitus[J].WJG,2014,20(39):14315-14328.
[4] 梅坚.2型糖尿病合并腹泻的临床特征及相关因素分析[J].中国中西医结合消化杂志,2013,21(4):197-199.
[5] BONFRATE L,PROCINO G,WANG D Q H,et al.A novel therapeutic effect of statins on nephrogenic diabetes insipidus[J].J Cell Mol Med,2015,19(2):265-282.
[6] 张玉萍,徐文阁.糖尿病皮肤感染与微生物菌群关系的研究进展[J].中国微生态学杂志,2013,25(11):1364-1365.
[7] SASONGKO M B,WONG T Y,NGUYEN T T,et al.Serum apolipoprotein AI and B are stronger biomarkers of diabetic retinopathy than traditional lipids[J].Diabetes Care,2011,34(2):474-479.
[8] WU Y Y,XIAO E,GRAVES D T.Diabetes mellitus related bone metabolism and periodontal disease[J].Int J Oral Sci,2015,7(2):63-72.
[9] 常宝成.2010版美国糖尿病协会《糖尿病诊疗标准》修订内容解读[J].国际内分泌代谢杂志,2010,30(5):294-295,301.
[10] MATHEWS C E,BROWN E L,MARTINEZ P J,et al.Impaired function of antibodies to pneumococcal surface protein A but not to capsular polysaccharide in Mexican American adults with type 2 diabetes mellitus[J].CVI,2012,19(9):1360-1369.
[11] 杜彩贺,胡芳,魏婷婷,等.PCR-DGGE指纹图谱技术分析2型糖尿病模型小鼠胃微生物菌群结构[J].中国生物工程杂志,2012,32(3):25-31.
[12] KIM J H,KWON H S,PARK Y M,et al.Prevalence and associated factors of diabetic retinopathy in rural Korea:the Chungju metabolic disease cohort study[J].J Korean Med Sci,2011,26(8):1068-1073.
[13] 江浪,李流连.乳酸杆菌水平与糖尿病患者糖脂及炎症指标相关性分析[J].检验医学与临床,2016,13(20):2916-2918.
[14] 陆颖影,胡国勇,王兴鹏,等.肠道菌群与相关代谢性及消化系统疾病的关系[J].国际消化病杂志,2015,35(2):126-128,146.
[15] 白钰,吕全胜,马晓丽,等.高膳食纤维低血糖生成指数饮食对2型糖尿病患者肠道菌群和血糖的影响研究[J].中国全科医学,2016,19(20):2469-2472.
[16] 吴文俊,项松英,沈飞霞,等.老年2型糖尿病患者肠道菌群的变化分析[J].中华全科医学,2014,12(5):743-744,767.
[17] 吴晓康,马超峰,余鹏博,等.2型糖尿病患者肠道乳酸菌属和消化链球菌属定量研究及其意义[J].西安交通大学学报:医学版,2015,36(1):93-97,134. |
