Objective: To investigate the clinical value of combined detection of serum thymidine kinase (TK1) and carbohydrate antigen 19-9 (CA19-9) in the differential diagnosis of pancreatic cancer and pancreatitis in patients with pancreatic cancer and pancreatitis. Methods: Eighty seven cases of patients with pancreatic cancer and 60 cases of acute pancreatitis patients from June 2015 to June 2016 were selected and analyzed in our hospital. Serum TK-1, CA19-9 level were detected,and the combined detecting value of differential diagnosis of pancreatic cancer and pancreatitis was evaluated. Results: Serum TK-1, CA19-9 in pancreatic cancer patients was higher than the average in pancreatitis group, the difference had statistical significance (P <0.05); serum ALT, AST and ALP levels in pancreatic cancer patients were lower than those in the acute pancreatitis group, the difference being statistical significant (P<0.05); the sensitivity of serum TK-1+CA19-9 in differential diagnosis of pancreatic cancer and pancreatitis was 90.80%, specificity was 95.00%, misdiagnosis rate 9.20%, misdiagnosis rate 5.00%, area under the ROC curve AUC 0.926.Conclusion: Combined detection of serum TK1 and CA19-9 in patients with pancreatic cancer and pancreatitis has high clinical value in the differential diagnosis of pancreatic cancer and pancreatitis. |
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