乌司他丁对急性心衰患者血管内皮功能和血清半乳凝素的影响-现代医学

乌司他丁对急性心衰患者血管内皮功能和血清半乳凝素的影响

作者：敖勇

单位：四川省仪陇县人民医院心血管内科, 四川仪陇 637600

分类号：R541

出版年·卷·期（页码）：2017·36·第八期（1109-1113）

摘要：

目的：探讨乌司他丁对急性心衰患者血管内皮功能和血清半乳凝素的影响。方法：选择2013年4月至2015年11月在我院治疗的急性心衰患者58例，根据随机数字表法分为对照组及观察组，各29例。两组患者均采取常规治疗，观察组患者在此基础上以乌司他丁治疗，观察两组患者的血管内皮功能、血清半乳素-3及NT-proBNP水平。结果：与治疗前相比，两组患者治疗后的LVEF、CO均明显升高，差异显著（P<0.05）。与对照组相比，观察组治疗后LVEF、CO均显著更高，差异显著（P<0.05）。与治疗前相比，两组患者的肱动脉FMD明显升高，差异显著（t=3.063、24.469，P<0.05）。与对照组相比，观察组治疗后肱动脉FMD明显更高，差异显著（t=15.561，P<0.05）。两组患者治疗前的Gal-3及NT-proBNP对比后，差异无统计学意义（P>0.05）。与治疗前相比，两组患者的Gal-3及NT-proBNP明显更低，差异有统计学意义（P<0.05）。与对照组相比，观察组治疗后的Gal-3、NT-proBNP水平显著更低（P<0.05）。结论：乌司他丁对急性心衰有确切临床疗效，可显著急性心衰患者血管内皮功能，降低患者血清半乳凝素-3含量。

Objective: To analyze the effect of ulinastatin on vascular endothelial function and serum galectin in patients with acute heart failure.Methods: 58 cases of patients with acute heart filure were selected from April 2013 to November 2015 in our hospital. According to the random number table method they were divided into control group and observation group, 29 cases in each. The patients in the observation group were treated additionally with ulinastatin on top of the routine treatment. Vascular endothelial function, serum galectin-3 and NT-proBNP were observed in the two groups. Results: LVEF and CO in the two groups were significantly higher than those before treatment(P<0.05). Compared with the control group, LVEF and CO in the observation group were significantly higher than those in the control group(P<0.05). Compared with before treatment, FMD of brachial artery was significantly increased in the two groups(t=3.063,24.469, P<0.05). Compared with the control group, FMD of the brachial artery in the observation group was significantly higher than that in the control group(t=15.561, P<0.05). There was no significant difference in Gal-3 and NT-proBNP between the two groups before treatment(P>0.05). The levels of Gal-3 and NT-proBNP were significantly lower in the two groups compared with those before treatment(P<0.05). Compared with the control group, the levels of Gal-3 and NT-proBNP in the observation group were significantly lower than those in the control group(P<0.05).Conclusion: Ulinastatin has a definite clinical efficacy on acute heart failure, for it can significantly improve endothelial function in patients with acute heart failure and reduce serum galectin-3 content.

参考文献：

[1] 高丽梅,区洁芬,侯香传.机械通气抢救老年急性左心衰竭患者的临床护理[J].护士进修杂志,2013,28(3):236-237.
[2] MCMURRAY J J V,ADAMOPOULOS S,ANKER S D,et al.ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012[J].Eur J Heart Fail,2012,14(8):803-869.
[3] YANCY C W,JESSUP M,BOZKURT B,et al.ACCF/AHA guideline for the management of heart failure:A report of the American college of cardiology foundation/American heart association task force on practice guidelines[J].Circulation,2013,128(16):1810-1852.
[4] 陈淼,武星,王国兴.心衰宁合剂对糖尿病心肌病患者心脏舒张功能的影响研究[J].现代中西医结合杂志,2016,25(25):2787-2789.
[5] 顾薇,李艳艳,吴立群,等.急性心力衰竭患者血清半乳凝素-3的变化及临床意义[J].内科理论与实践,2014,9(3):174-178.
[6] 姜镕,马春华,朱子龙,等.脑脊液循环肿瘤细胞检测在非小细胞肺癌脑膜转移诊断中的应用[J].中国现代神经疾病杂志,2014,14(8):704-707.
[7] JESSUP M,ABRAHAM W T,CASEY D E,et al.2009 focused update:ACCF/AHA guidelines for the diagnosis and management of heart failure in adults[J].Circulation,2009,119(14):1977-2016.
[8] HEIDENREICH P A,ALBERT N M,ALLEN L A,et al.Forecasting the impact of heart failure in the united states a policy statement from the american heart association[J].Circ Heart Fail,2013,6(3):606-619.
[9] 吴剑弟,梁健球,李琛,等.乌司他丁治疗心力衰竭伴胸腔积液的效果[J].广东医学,2015,36(15):2410-2412.
[10] 苗雪松,刘大东,吕明阳,等.乌司他丁治疗急性心衰患者临床疗效观察[J].中国现代药物应用,2016,10(19):29-31.
[11] 魏群,周萍.前列地尔对老年慢性心功能不全患者心功能及脑钠肽的影响[J].实用临床医学,2012,13(12):47-48.
[12] RAYEGANI F,ONWUBOLU G C.Fused deposition modelling(FDM)process parameter prediction and optimization using group method for data handling(GMDH)and differential evolution(DE)[J].Int J Adv Manuf Tech,2014,73(1):509-519.
[13] PANDA B N,BBHUBALENDRUNI M V A R,BISWAL B B.A general regression neural network approach for the evaluation of compressive strength of FDM prototypes[J].Neural Comput Appl,2015,26(5):1129-1136.
[14] VOLAREVIC V,MARKOVIC B S,BOJIC S,et al.Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury[J].Eur J Immunol,2015,45(2):531-543.
[15] 李淑娟,崔晓迎,段莎莎,等.实时三维超声心动图联合血浆NT-proBNP评估心衰患者左室收缩同步性的研究[J].中国心血管病研究,2016,14(9):796-800.
[16] 张志宏,张丽华,郑春霞,等.应用半乳糖凝集素3及成纤维细胞生长因子23评估慢性肾脏病患者的心血管危险因素[J].肾脏病与透析肾移植杂志,2016,25(4):301-307.

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