Objective:To compare the prognosis of physiological bronchopulmonary dysplasia of newborn (BPD) treated withdifferent mechanical ventilation strageties. Methods:From August 2013 to May 2016, 56 physiological BPD treated in our hospital were selected as the research object, all the newborns were divided into observation group and control group, 28 patients in each, according to the random draw envelope principle, the observation group was given high frequency oscillatory ventilation treatment, the control group was given routine treatment with continuous positive airway pressure, the prognosis of two groups were observed and recorded. Results:The oxygen exposure time and mechanical ventilation time in the observation group were(170.14±22.19) h and (115.29 ±12.59) h, respectively, being significantly less than (214.95±13.29) h and (138.20±17.44) h in the control group(P<0.05). PaO2 and PaCO2 values in the two groups were not statistically significant 48 h before and after treatment(P>0.05); The OI values 48 h after treatment in the observation group and the control group were 10.37±2.19 and 12.49±3.19, respectively, being significantly lower than those before treatment 16.39±4.22 and 16.22±3.87 (P<0.05); furthermore the OI value 48h after treatment in the observation group was significantly lower than that in the control group(P<0.05). 7.1%of the patients encountered lung leakage, intracranial hemorrhage, pulmonary hemorrhage and complication rate in the observation group during treatment, while 35.7% in the control group, the incidence of complications of in the observation group was significantly lower than that of the control group(P<0.05). Conclusion:Compared with conventional mechanical ventilation, the application of high frequency oscillatory ventilation in the treatment of physiological BPD can improve oxygenation index, shorten the oxygen exposure time and mechanical ventilation time, and reduce the incidence of complications.
 WAITZ M, MENSE L, KIRPALANI H, et al. Nasal intermittent positive pressure ventilation for preterm neonates:synchronized or not?[J].Clin Perinatol,2016,43(4):799-816.
 WRIGHT C J, POLIN R A. Noninvasive support:does it really decrease bronchopulmonary dysplasia?[J].Clin Perinatol,2016,43(4):783-798.
 WELTY S E. Continuous positive airway pressure strategies with bubble nasal continuous positive airway pressure:not all bubbling is the same:the seattle positive airway pressure system[J].Clin Perinatol,2016,43(4):661-671.
 JOSS-MOORE L A, HAGEN-LILLLEVIK S J, YOST C, et al.Alveolar formation is dysregulated by restricted nutrition but not excess sedation in preterm lambs managed by noninvasive support[J].Pediatr Res,2016,80(5):719-728.
 KENNEDY K A, COTTEN C M, WATTERBERG K L, et al. Prevention and management of bronchopulmonary dysplasia:Lessons learned from the neonatal research network[J].Semin Perinatol,2016,40(6):348-355.
 BASHIR R A, BHANDARI V, VAYALTHRIKKOVI L, et al. Chorioamnionitis at birth does not increase the risk of neurodevelopmental disability in premature infants with bronchopulmonary dysplasia[J].Acta Paediatr,2016,105(11):506-512.
 ISAYAMA T, IWAMI H, MCDONALD S, et al. Association of noninvasive ventilation strategies with mortality and bronchopulmonary dysplasia among preterm infants:a systematic review and meta-analysis[J].JAMA,2016,316(6):611-624.
 SCHREINER C, SCHREINER F, HARTEL C, et al. Glucocorticoid receptor gene variants and neonatal outcome in very-low-birth-weight preterm infants[J].Neonatology,2016,111(1):22-29.
 JIANG Q, GAO X, LIU C, et al. Early inhaled nitric oxide in preterm infants <34 weeks with evolving bronchopulmonary dysplasia[J].J Perinatol,2016,36(10):883-889.
 MEINERS S, HILGENDORFF A. Early injury of the neonatal lung contributes to premature lung aging:a hypothesis[J].Mol Cell Pediatr,2016,3(1):24-27.
 WAI K C, KOHN M A, BALLARD R A, et al. Early cumulative supplemental oxygen predicts bronchopulmonary dysplasia in high risk extremely low gestational age newborns[J].J Pediatr,2016,177(11):97-102.
 BRYKSINA E Y, BRYKSIN V S, PPCHIVALOV A V. Incidence, pathomorphism and outcomes of the bronchopulmonary dysplasia associated with microaspiration of gastric contents[J].Vestn Ross Akad Med Nauk,2016,12(2):128-140.