CT引导下经皮微波消融术治疗特殊部位小肝癌36例临床研究-现代医学

CT引导下经皮微波消融术治疗特殊部位小肝癌36例临床研究

单位：1. 东南大学附属第二医院肿瘤科, 江苏南京 210003;
2. 东南大学附属第二医院放射科, 江苏南京 210003

分类号：R735.7;R730.59

出版年·卷·期（页码）：2017·36·第十一期（1568-1572）

摘要：

目的：回顾性分析CT引导下经皮微波消融（CT-MWA）治疗特殊部位小肝癌的临床疗效及安全性。方法：对2009年8月至2015年5月行CT-MWA治疗的36例小肝癌患者的临床资料进行回顾性分析。分析总结微波消融治疗小肝癌的1、2、3年生存率、完全消融率、局部进展率、并发症及不良反应。结果：36个小病灶行CT-MWA治疗的成功率和完全消融率分别为97.22%（35/36）和88.89%（32/36）。术后轻度肝功能异常5例，肝区疼痛轻度6例、中度3例、重度0例，恶心呕吐3例，食欲下降5例，腹胀3例，发热7例。中位局部无复发时间为15.22个月。术后3、6、12个月及1年以上的肿瘤局部进展率分别为5.56%（2/36）、5.56%（2/36）、11.11%（4/36）、19.44%（7/36）。36例患者的1、2、3生存率分别为86.67%（31/36）、58.33%（21/36）、47.22%（17/36）。结论：CT-MWA治疗特殊部位小肝癌是一种安全有效的微创治疗方法。

Objective:To retrospectively analyze the clinical efficacy and safety of CT guided percutaneous microwave ablation(CT-MWA) for small hepatocellular carcinoma(HCC) with specific liver lesions. Methods:36 patients with small HCC treated with CT-MWA from August 2009 to May 2015 were collected and retrospectively analyzed. The 1-, 2- and 3-year overall survival rate, complete ablation rate, local rate of progress, complications and adverse reactions were calculated and summarized. Results:The success rate of CT-MWA and complete ablation rate of 36 small lesions were 97.22%(35/36) and 88.89%(32/36), respectively. The results of postoperative complication showed that there were 5 cases with mild liver dysfunction, 6 cases with mild hepatalgia, 3 cases with moderate hepatalgia, none with severe hepatalgia, 3 cases with nausea and vomiting, 5 cases with anorexia, 3 cases with abdominal distention and 7 cases with fever. The median local recurrence time was 15.22 months. The rates of local tumor progression at 3, 6, 12 months and 1 years after surgery were 5.56%(2/36), 5.56%(2/36), 11.11%(4/36) and 19.44%(7/36), respectively. The 1-,2- and 3-year survival rate of these 36 patients was 86.67%(31/36), 58.33%(21/36), and 47.22%(17/36), respectively. Conclusion:CT-MWA is a safe and effective minimally invasive treatment for small HCC of specifically located liver lesions.

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