超声心动图引导下经胸微创封堵术对先天性心脏病患者心肌重构及血小板活化的影响-现代医学

超声心动图引导下经胸微创封堵术对先天性心脏病患者心肌重构及血小板活化的影响

单位：1. 陕西省核工业二一五医院心胸外科, 陕西咸阳 712000;
2. 上海远大心胸医院心胸外科, 上海 200235;
3. 西京医院心胸外科, 陕西西安 710032

分类号：R654.2

出版年·卷·期（页码）：2017·36·第十一期（1607-1611）

摘要：

目的：探讨超声心动图引导下经胸微创封堵术对先天性心脏病（congenital heart disease，CHD）患者心肌重构及血小板活化的影响。方法：选择2014年2月至2016年2月陕西省核工业二一五医院心胸外科收治的76例CHD患者，将患者随机分为对照组和观察组，每组各38例。对照组采用经皮介入封堵术，观察组应用超声心动图引导下经胸微创封堵术。比较两组手术成功率、心肌重构与血小板活化情况及并发症发生率。结果：观察组手术成功率为97.37%，略高于对照组的94.74%，但差异无统计学意义（P>0.05）；观察组心肌重构逆转程度明显大于对照组，差异有统计学意义（P<0.05）；两组术后血小板活化程度、并发症发生率相比，差异均无统计学意义（P>0.05）。结论：超声心动图引导下经胸微创封堵术治疗CHD，可有效逆转心肌重构，改善患者心肌功能，提高手术安全性。

Objective:To investigate the influence of ultrasonic cardiogram(UCG) guided minimally invasive transthoracic occlusion on myocardial remodeling and platelet activation in patients with congenital heart disease (CHD). Methods:76 CHD patients admitted into our institution from February 2014 to February 2016 were selected, and they were randomly divided into observation group and control group, 38 cases in each. The control group was given percutaneous interventional occlusion, while the observation group was given UCG guided minimally invasive transthoracic occlusion. The success rate of operation, myocardial remodeling, platelet activation and the incidence of complications were compared between the two groups. Results:The success rate of operation in the observation group(97.37%) was compared with that in control group(94.74%), there was no statistical difference(P>0.05); The reversal degree of myocardial remodeling in the observation group was significantly higher than that in the control group with a statistical difference(P<0.05); After the operation, the degree of platelet activation and the incidence of complications were compared between the two groups, there was no statistical difference(P>0.05). Conclusion:UCG guided minimally invasive transthoracic occlusion in treating CHD can effectively reverse myocardial remodeling, as well as improve myocardial function and the safety of operation.

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