Objective:To observe the adverse reactions of oral administration of Harvoni and the effect of individualized nursing care intervention on the cure rate and quality of life to hemodialysis patients with hepatitis C virus(HCV) infection. Methods:12 maintenance hemodialysis patients with HCV infection received oral Harvoni treatment, which lasted 12 weeks in patients without live cirrhosis, 24 weeks in patients with liver cirrhosis. During treatment, close observation and recording of patients, and individualized nursing measures were taken during the dialysis. The quantitative indexes of virus were detected respectively after the treatment of Harvoni orally for 2 weeks. The SF-36 scale was used to assess the quality of life of patients before and after treatment. The main side effects were fatigue, headache, nausea, diarrhea, and anxiety. The adverse reactions were improved after the intervention of individual nursing care. Results:All patients completed the standard course of treatment. The early response rate was 100%. At the end of treatment, serum ALT was normal, serum HCV-RNA was negative (<1 000 IU·ml-1) and the sustained response rate was 100%. The results of SF-36 showed that the scores of physical pain, general health, vitality, social function and mental health of the patients were significantly higher than those before the medication(P<0.05), and the difference was statistically significant. Conclusion:Individualized nursing care intervention for dialysis patients with HCV infection during oral administration of Harvoni can achieve clinical cure of hepatitis C, reduce the duration of adverse reactions, and promote physical function and mental health, as well as improve the quality of life. |
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