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PRP治疗难愈性骨或腱性组织外露创面的疗效分析
作者:杨蔡伟1  熊敏1  冒海军2 
单位:1. 溧阳市中医院 手外科, 江苏 常州 213300;
2. 南京大学医学院附属南京鼓楼医院 手外科, 江苏 南京 210000
关键词:难愈性骨创面 腱性组织外露创面 富血小板血浆 修复 
分类号:R685
出版年·卷·期(页码):2017·36·第十二期(1704-1708)
摘要:

目的:探讨富血小板血浆(PRP)治疗难愈性骨或腱性组织外露创面的临床疗效。方法:选取溧阳市中医院收治的30例难愈性骨或腱性组织外露创面患者作为研究对象,所有患者在进行清创处理后,均运用自体PRP伤口内注射进行治疗,观察创面愈合情况。结果:首次PRP注射治疗10 d后创面修复情况良好,25例的外露肌肉/骨组织表面有新生肉芽组织覆盖,创面内的坏死组织及脓苔消失,创面色泽红润、血供良好,与PRP治疗前相比差异有统计学意义(P<0.05)。PRP治疗前的创面体积为(12.75±2.46) cm3,PRP治疗2次后的创面体积为(3.22±1.14) cm3,治疗前后的创面体积比较差异有统计学意义(P<0.05)。PRP治疗2次后的平均创面覆盖率显著高于治疗前(P<0.05)。PRP治疗2次后的创面愈合率为33.33%。结论:难愈性骨创面或腱性组织外露创面运用自体PRP进行治疗,能够有效促进软组织修复,加快创面愈合,缩短治疗周期,值得推广。

Objective: To evaluate the clinical efficacy of platelet rich plasma (PRP) treatment on refractory bone wound or tendon tissue exposed wounds.Methods: 30 cases of refractory bone wound or tendon tissue exposed wounds patients in Liyang Hospial of Traditional Chinese Medicine were chosen for the study. after making debridement, all patients were treated with autologous PRP injection. The wound healing situation were observed.Results: The wound was repaired well after the first PRP injection for 10 days. 25 cases of patients' exposed muscle/bone tissue surface had new granulation tissue coverage, the necrotic tissue and pus moss disappeared in the wound, the color of the wound was ruddy and the blood supply was good. There was significant difference compared with before PRP treatment (P<0.05). The wound volume before PRP treatment was (12.75±2.46)cm3, and the wound volume after PRP treatment was (3.22±1.14) cm3. There was significant difference between before and after PRP treatment (P<0.05). The mean wound coverage after PRP treatment was significantly higher than that before PRP treatment (P<0.05). The wound healing rate was 33.33% after 2 times of PRP treatment.Conclusion: The use of autologous PRP in the treatment of refractory wound or tendon tissue exposed wounds can effectively promote soft tissue repair, accelerate wound healing, shorten the treatment cycle, and be worthy of promotion.

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