目的：探讨组蛋白脱乙酰酶11（HDAC11）调节垂体瘤中细胞凋亡的作用机制。方法：选取我院2015年1月至2016年12月收集的垂体瘤标本50例，同时选取距离肿瘤边缘>2 cm的癌旁组织作为对照。所有标本均经病理诊断证实，术前患者未经放疗、化疗。SYBR green实时荧光定量PCR法检测不同亚型组HDAC11的相对表达量，并分析其与p53的相关性以及相互作用机制。结果：（1） HDAC11与垂体瘤细胞中p53的表达呈负相关；（2） HDAC11在垂体瘤细胞中与HEY1形成了一个复合体；（3） HDAC11可以使垂体瘤细胞中HEY1去乙酰化；（4） HDAC11抑制垂体瘤细胞中p53的表达。结论：垂体瘤细胞中高表达HDAC11，而HDAC11可以抑制p53在垂体肿瘤细胞中的表达，HDAC11在垂体瘤的发生发展中起着重要作用。

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