Objective:To investigate the diffrences ofcurative effect of nucleoside medicineand interferon on hepatitis B with different genes and mutation. Methods:Four hundreds and thirty-one cases of hepatitis B were underwent the genotyped and gene mutation detection, and then divided into interferongroup (n=216) and nucleosidegroup (n=215)according to the treatment method. After 48 weeks the curative effect and treatment response rate were compared between the two groups.Results:There were 292 cases (67.75%) of HBV-B and 139 (32.25%) cases of HBV-C. There were 13 cases of primary resistance mutation and 63 cases of secondary resistance gene mutation. After 48 weeks of treatment,the normalization rate of ALT and the negative rate of HBV-DNA in nucleoside group were higher than those in interferon group (P<0.01), HBeAg negative rate, HBeAg conversion rate were lower than those in interferon group (P<0.01).HBV-B and HBV-C type patients response rate has no significant difference (P>0.05) in nucleotide group. There was no significant difference among the primary, secondary and non-mutated patients (P<0.01). In the interferon group, the treatment response rate of the HBV-B patients was significantly higher than that of HBV-C patients (P<0.05).There was no significant difference among the primary, secondary and non-mutated patients (all P>0.05). Conclusion:The treatment of Hepatitis B should be based on the patient's genotyping and gene mutation to select drugs rationally. At the same time, the drug resistance genes should be monitored. Whenresistance caused bygene mutation happens, the treatment plan should be adjusted as soon as possible to obtain the best treatment effect. |
[1] 崔富强.中国人群乙型病毒性肝炎血清流行病学调查-乙型肝炎疫苗接种降低乙型肝炎病毒感染率[J].中国疫苗和免疫,2010,16(4):341-344.
[2] LIU J,ZHANG S,WANG Q,et al.Seroepidemiology of hepatitis B virus infection in 2 million men aged 21-49 years in rural China:a population-based,cross-sectional study[J].Lancet Infect Dis,2015,16(1):80-86.
[3] FUNG J,WONG T,CHOK K,et al.Oral nucleos(t)ide analogs alone after liver transplantation in chronic hepatitis B with preexisting rt204 mutation[J].Transplantation,2017,101(10):2391-2398.
[4] ZHOU J,LIU Y Y,LIAN J S,et al.Efficacy and safety of tenofovir disoproxil treatment for chronic hepatitis B patients with genotypic resistance to other nucleoside analogues:A prospective study[J].Chin Med J (Engl),2017,130(8):914-919.
[5] ZHANG Y R,LI B,WANG C X,et al.Influence of Treg cells and HBV genotype on sustained response and drug resistance in the treatment with nucleoside drugs[J].Braz J Med Biol Res,2017,50(3):e5796.
[6] STANAWAY J D,FLAXMAN A D,NAGHAVI M,et al.The global burden of viral hepatitis from 1990 to 2013:findings from the Global Burden of Disease Study 2013[J].Lancet,2016,388(10049):1081-1088.
[7] 李少雄,符辉,杨思谋,等.HBeAg阳性慢性乙型肝炎患儿应用聚乙二醇干扰素α-2a治疗的效果观察[J].中国中西医结合消化杂志,2017,25(5):360-364.
[8] 安丽娜,吴玮,孙晓慧,等.聚乙二醇干扰素α-2a并恩替卡韦治疗HBeAg阳性慢性乙型肝炎的效果[J].齐鲁医学杂志,2016,31(3):366-368.
[9] 陈焕文.核苷类药物与聚乙二醇干扰素α-2a在乙型肝炎治疗中的临床应用[J].慢性病学杂志,2017,18(2):164-166.
[10] PACHECO S R,DOS S M,STOCKER A,et al.Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B[J].Infect Drug Resist,2017,10:201-207.
[11] AGUILERA A,NAVARRO D,RODRIGUEZ F F,et al.Prevalence and distribution of hepatitis C virus genotypes in Spain during the 2000-2015 period[J].J Viral Hepat,2017,24(9):725-732.
[12] STASI C,SILVESTRI C,VOLLER F.Emerging trends in epidemiology of hepatitis B virus infection[J].J Clin Transl Hepatol,2017,5(3):272-276. |