[1] KOWAL J,TKACH M,THÉRY C.Biogenesis and secretion of exosomes[J].Curr Opin Cell Biol,2014,29:116-125.
[2] XU R,GREENING D W,ZHU H J,et al.Extracellular vesicle isolation and characterization:toward clinical application[J].J Clin Invest,2016,126(4):1152-1162.
[3] ABELS E R,BREAKEFIELD X O.Introduction to extracellular vesicles:biogenesis,RNA cargo selection,content,release,and uptake[J].Cell Mol Neurobiol,2016,36(3):301-312.
[4] FAURÉ J,LACHENAL G,COURT M,et al.Exosomes are released by cultured cortical neurons[J].Mol Cell Neurosci,2006,31(4):642-648.
[5] YUYAMA K,SUN H,MITSUTAKE S,et al.Sphingolipid-modulated exosome secretion promotes clearance of amyloid-beta by microglia[J].J Biol Chem,2012,287(14):10977-10989.
[6] BAKHTI M,WINTER C,SIMONS M.Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles[J].J Biol Chem,2011,286(1):787-796.
[7] MATHIVANAN S,FAHNER C J,REID G E,et al.ExoCarta 2012:database of exosomal proteins,RNA and lipids[J].Nucleic Acids Res,2012,40(Database issue):D1241-1244.
[8] COLOMBO M,RAPOSO G,THÉRY C.Biogenesis,secretion,and intercellular interactions of exosomes and other extracellular vesicles[J].Annu Rev Cell Dev Biol,2014,30:255-289.
[9] VLASSOV A V,MAGDALENO S,SETTERQUIST R,et al.Exosomes:current knowledge of their composition,biological functions,and diagnostic and therapeutic potentials[J].Biochim Biophys Acta,2012,1820(7):940-948.
[10] SHARMA P,SCHIAPPARELLI L,CLINE H T.Exosomes function in cell-cell communication during brain circuit development[J].Curr Opin Neurobiol,2013,23(6):997-1004.
[11] TAKAHASHI R H,MILNER T A,LI F,et al.Intraneuronal Alzheimer Aβ 42 accumulates in multivesicular bodies and is associated with synaptic pathology[J].Am J Pathol,2002,161(5):1869-1879.
[12] RAJENDRAN L,HONSHO M,ZAHN T R,et al.Alzheimer's disease β-amyloid peptides are released in association with exosomes[J].Proc Natl Acad Sci,2006,103(30):11172-11177.
[13] SULLIVAN C P,JAY A G,STACK E C,et al.Retromer disruption promotes amyloidogenicAPP processing[J].Neurobiol Dis,2011,43(2):338-345.
[14] JOSHI P,TUROLA E,RUIZ A,et al.Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles[J].Cell Death Differ,2014,21(4):582-593.
[15] SAMAN S,KIM W,RAYA M,et al.Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease[J].J Biol Chem,2012,287(6):3842-3849.
[16] ASAI H,IKEZU S,TSUNODA S,et al.Depletion of microglia and inhibition of exosome synthesis halt tau propagation[J].Nat Neurosci,2015,18(11):1584-1593.
[17] WANG G,DINKINS M,HE Q,et al.Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4(PAR-4):potential mechanism of apoptosis induction in Alzheimer disease[J].J Biol Chem,2012,287(25):21384-21395.
[18] CUI G H,WU J,MOU F F,et al.Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory response in APP/PS1 mice[J].FASEB J,2017,[Epub ahead of print].
[19] DINKINS M B,DASGUPTA S,WANG G,et al.Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease[J].Neurobiol Aging,2014,35(8):1792-1800.
[20] YUYAMA K,SUN H,SAKAI S,et al.Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice[J].Biol Chem,2014,289(35):24488-24498.
[21] KATSUDA T,TSUCHIYA R,KOSAKA N,et al.Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes[J].Sci Rep,2013,3:1197.
[22] AN K,KLYUBIN I,KIM Y,et al.Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo[J].Mol Brain,2013,6:47.
[23] FIANDACA M S,KAPOGIANNIS D,MAPSTONE M,et al.Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes:a case-control study[J].Alzheimer's Dement,2015,11(6):600-607.
[24] LUGLI G,COHEN A M,BENNETT D A,et al.Plasma exosomal miRNAs in persons with and without Alzheimer disease:altered expression and prospects for biomarkers[J].PLoS One,2015,10(10):e0139233.
[25] LIU C G,SONG J,ZHANG Y Q,et al.MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease[J].Mol Med Rep,2014,10(5):2395-2400. |
