目的：探讨颅内动脉瘤破裂经介入治疗前后血清基质金属蛋白酶-2，MMP-2）和基质金属蛋白酶-9（MMP-9）含量变化及对预后影响的相关因素分析。方法：140例行介入栓塞治疗的颅内动脉瘤破裂患者作为实验组，对未破裂颅内动脉瘤80例患者作为对照组。对实验组术前、术后第3天、1周、1月抽取外周静脉血分析血清MMP-2和MMP-9值，对照组抽取外周静脉血分析血清MMP-2和MMP-9值，出院后经GOS评分结果作为评判介入治疗是否有效，了解血清MMP-2、MMP-9与术前对预后有影响的相关危险因素经Logistic回归分析。结果：颅内动脉瘤破裂经介入栓塞术前血清MMP-2、MMP-9含量明显高于对照组，差异具有统计学意义（P < 0.05），术后3 d、1周血清内MMP-2含量明显高于术前，术后1月血清MMP-2含量较术前明显降低，差异有统计学意义（P < 0.05），术后3 d、1周、1月血清MMP-9含量明显高于术前，差异有统计学意义（P < 0.05）；出院时行GOS评分，患者中预后良好119例（约85%），预后较差21例（约15%）；对预后有影响的相关危险因素经logistic回归进行分析，发现脑血管痉挛、高Hunt-Hess分级（Ⅲ）、再出血对术后的预后有较大的影响，差异有统计学意义（P < 0.05）；在不同Hunt-Hess分级、脑血管痉挛的严重程度下，血清MMP-2、MMP-9含量变化较大；血清MMP-2、MMP-9、Hunt-Hess分级及脑血管痉挛度在ROC曲线面积为89%、80%、75%及72%，敏感性、特异性都高于90%，且血清MMP-2和MMP-9在本研究中最佳诊断界点为124 ng·ml^-1和321 ng·m^-1。结论：血清MMP-2、MMP-9含量变化对预后有较大的影响，可对预后评估有指导意义。

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