Objective: To explore the expression of beclin-1 and bcl-2 in prostate cancer and its clinical significance. Methods: The protein expression of beclin-1, bcl-2 was measured by immunohistoehemistry assay in seventy-five prostate cancer tissues, forty high grade prostatic intraepithelial neoplasia tissues and forty benign prostatic hyperplasia tissues, The relationship between beclin-1, bcl-2 and prostate cancer patients clinical data were compared. Results: The positive rate of beclin-1 protein in the PC group was 54.7%(41/75), 67.5%(27/40) in the HGPIN group and 92.5%(37/40) in the BPH group, the positive rate of beclin-1 protein in the PC group was significantly lower than that in the HGPIN group and BPH group, and HGPIN group was significantly lower than that in the BPH group, the difference was statistically significant(P<0.05). The positive rate of bcl-2 protein in the PC group was 85.4%(64/75), 60.0%(24/40) in the HGPIN group and 32.5%(13/40) in the BPH group, the positive rate of bcl-2 protein in the PC group was significantly higher than that in the HGPIN group and BPH group, and HGPIN group was significantly higher than that in the BPH group, the difference was statistically significant(P<0.05). There was no significant difference between beclin-1, bcl-2 and patients age, pathological grade, prostatitis history and lymph node metastasis(P>0.05), the score of Gleason in prostate cancer was higher, the positive rate of beclin-1 was weaker, and the positive rate of bcl-2 was stronger, the difference was statistically significant(P<0.05). The grade of TNM stage in prostate cancer was higher, the positive rate of beclin-1 was weaker, and the positive rate of bcl-2 was stronger, the difference was statistically significant(P<0.05). Beclin-1 expression was found to have negative correlation with bcl-2 in prostate cancer(r=-0.241, P < 0.05). Conclusion: Down-expression of beclin-1 gene and over-expression of bcl-2 gene exit in prostate cancer, beclin-1/bcl-2 may contribute to regulate the tumorigenesis and development of PC cells. |
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