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H型高血压患者血清同型半胱氨酸水平与冠状动脉狭窄程度的关系
作者:刘亚东  孙娟  程向明  高强 
单位:延安大学附属医院 检验科, 陕西 延安 716000
关键词:H型高血压 冠心病 同型半胱氨酸 冠状动脉狭窄 
分类号:R544.11
出版年·卷·期(页码):2018·46·第五期(526-528)
摘要:

目的:探讨H型高血压患者血清同型半胱氨酸(Hcy)水平与冠状动脉狭窄的关系。方法:选取95例H型高血压合并冠状动脉性心脏病(CHD)患者(血清Hcy ≥ 10 μmol·L-1)为实验组,同时选取79例原发性高血压合并CHD患者(血清Hcy<10 μmol·L-1)为对照组,比较两组性别,年龄,吸烟史,收缩压,舒张压,血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇、超敏C-反应蛋白、铁蛋白水平和冠状动脉Gensini积分。结果:实验组Hcy水平显著高于对照组[(34.22±18.26)μmol·L-1 vs(7.02±2.34)μmol·L-1]。实验组冠状动脉Gensini积分显著高于对照组,两组患者冠状动脉狭窄程度差异有统计学意义(P<0.01)。相关性分析显示,实验组患者血清Hcy水平与Gensini积分呈正相关(r=1,P=0.000)。结论:血清Hcy水平是CHD独立的危险因素,H型高血压患者血清Hcy水平与冠状动脉狭窄程度呈正相关。

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