Objective:To explore the application of amplitude integrated electroencephalogram (aEEG) combined with C-reactive protein (CRP) level in early diagnosis of premature brain injury. Methods:90 cases of preterm infants with high risk of brain injury were selected to monitor the aEEG and the level of CRP. According to magnetic resonance imaging (MRI), they were divided into brain injury group (52 cases) and non brain injury group (38 cases). The sensitivity and specificity of aEEG and CRP level in early diagnosis of premature brain injury were analyzed. Results:In early diagnosis of premature brain injury, the sensitivity was 82.69%, 71.15%, 92.30%, and the specificity was 73.28%, 84.21%, 68.42% for aEEG alone, CRP level alone and combined use of both. The combined use of aEEG and CRP level to diagnose brain injury in premature infants could significantly increase the sensitivity (P<0.05), and the area under the ROC curve was the maximum, it was 0.804. Conclusion:The monitoring of CRP level can be used as a supplementary technology for monitoring the brain damage of premature infants in early diagnosis by aEEG, which could improve the actual diagnosis effect. |
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