丹酚酸A（salvianolic acid A，Sal A）是一种从丹参根部提取出来的水溶性酚酸，由一分子丹参素与两分子咖啡酸缩合而成，是丹酚酸（salvianolic acids，SA）的主要活性成分。由于Sal A有显著保护缺血心肌、抗肝纤维化、抗氧化、抗血栓、神经保护等药理活性，多年以来一直是科研工作者研究的热点。在脑缺血再灌注（ischemia reperfusion，I/R）损伤中，Sal A可通过抗炎、抗细胞凋亡、抗氧化应激、保护血脑屏障等多方面机制促进神经功能恢复，发挥有效的脑保护作用。现对Sal A在缺血性卒中脑保护作用机制的最新研究进展加以综述，为其进一步研究开发提供参考。

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