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乳腺癌组织中KIF15的表达及其与临床病理及预后的关系
作者:韩学艳  李畅 
单位:南京医科大学附属淮安第一医院 检验科, 江苏 淮安 223001
关键词:驱动蛋白成员15 表达 乳腺癌 转移 预后 
分类号:R446
出版年·卷·期(页码):2018·46·第七期(781-784)
摘要:

目的:探讨乳腺癌组织中驱动蛋白成员15(KIF15)的表达及其与临床病理参数及乳腺癌预后的关系。方法:利用免疫组织化学法检测140例乳腺癌组织和对应癌旁组织中KIF15的表达。KIF15在乳腺癌组织与癌旁组织中表达的差异采用Pearson卡方检验,KIF15表达与患者临床病理参数之间的关系采用Pearson卡方检验和Fisher精确检验,采用Kaplan-Meier法分析KIF15阴性和阳性患者之间总体生存率和无复发生存率,比较采用Log-Rank检验。结果:KIF15阳性率乳腺癌组织为64.3%,癌旁组织为17.9%,两者差异有统计学意义(χ2=62.345,P<0.001)。乳腺癌组织中KIF15表达与肿瘤大小、淋巴结转移、TNM分期、Ki-67和Bcl-2相关。生存分析显示,乳腺癌的总体生存率和无复发生存率KIF15阳性患者显著低于KIF15阴性患者。结论:KIF15在乳腺癌组织中高表达,其高表达可能与肿瘤增殖、转移及预后有关。

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