目的：研究慢性肝病（CLD）住院患者生活质量与疲劳及睡眠状况的关系，为实施必要的干预措施提供依据。方法：运用生存质量测评量表（SF-36）、疲劳量表（FS-14）及匹兹堡睡眠质量指数（PSQI）量表对77例CLD住院患者进行调查分析。结果：CLD住院患者SF-36中生理功能、生理职能、躯体疼痛、总体健康、活力、社会功能、情感职能和精神健康分别为（82.40±17.35）、（48.38±41.43）、（77.60±23.25）、（52.73±20.54）、（67.60±19.56）、（72.15±23.13）、（54.55±41.15）和（73.35±18.85）分，生理健康总分和心理健康总分分别为（65.28±19.17）分和（66.92±19.98）分。与常模相比，CLD住院患者疲劳总分、躯体疲劳及精神疲劳得分增加，分别为[（7.03±3.399）分，P=0.000]、[（4.40±2.488）分，P=0.017]、[（2.62±1.522）分，P=0.000]。CLD住院患者睡眠障碍者占41.6%，与常模相比，PSQI总分[（7.05±4.154）分]明显增高，差异有统计学意义（P<0.001）；PSQI中的睡眠质量、睡眠延迟、睡眠时间、睡眠效率、睡眠障碍、睡眠药物及日间功能等7个维度分别为（1.21±1.07）、（1.12±1.06）、（1.06±1.07）、（1.18±1.11）、（1.11±0.57）、（0.06±0.296）及（1.19±0.641）分。逐步多元线性回归分析显示，躯体疲劳、文化程度、日间功能、睡眠效率对躯体健康有影响（F=18.074，P=0.000）；躯体疲劳、文化程度、日间功能及睡眠时间对精神健康有影响（F=21.186，P=0.000）。结论：CLD住院患者疲劳感及睡眠障碍明显；躯体疲劳和睡眠障碍是影响这些患者生活质量的重要负性因素，而文化程度是影响患者生活质量的重要正性因素。

[1] CHE Y H,YOU J,CHONGSUVIVATWONG V,et al.Dynamics and liver disease specific aspects of quality of life among patients with chronic liver disease in Yunnan,China[J].Asian Pac J Cancer Prev,2014,15(12):4765-4771.
[2] YOUNOSSI Z M,KIWI M L,BOPARAI N,et al.Cholestaticliver diseases and health-related quality of life[J].Am J Gastroenterol,2000,95(2):497-502.
[3] SOBHONSLIDSUK A,SILPAKIT C,KONGSAKON R,et al.Factors influencing health-related quality of life in chronic liver disease[J].World J Gastroenterol,2006,12(48):7786-7791.
[4] von WAGNER M,LEE J H,KRONENBERGER B,et al.Impairedhealth-related quality of life in patients with chronic hepatitis C and persistently normal aminotransferase levels[J].J Viral Hepatitis,2006,13(12):828-834.
[5] GUTTELING J J,de MAN R A,BUSSCHBACH J J, et al.Overview of research on health-related quality of life in patients with chronic liver disease[J].Neth J Med,2007,65(7):227-234.
[6] UNAL G,de BOER J B,BORSBOOM G J,et al.A psychometric comparison of health-related quality of lifemeasures in chronic liver disease[J].J Clin Epidemiol,2001,54(6):587-596.
[7] 张作记.行为医学量表手册[M].北京:中华医学电子音像出版社,2005:392,490-491.
[8] 刘贤臣,唐茂芹.匹兹堡睡眠质量指数的信度和效度研究[J].中华精神科杂志,1996,29(2):1103-1107.
[9] ZWARTS M J,BHIJENBERG G,van ENGELEN B G.Clinical neurophysiology of fatigue[J].Clin Neurophysiol,2008,119(1):2-10.
[10] 肖琳,张韬,肖钧刚,等.83例原发性胆汁性肝硬化的临床分析[J].中国肝脏病杂志(电子版),2010,2(2):12-15.
[11] SHARPE M C,ARCHARD L C,BANATVALA J E,et al.A report:chronic fatigue sydrome:guideline for research[J].J R Soc Med,1991,84(2):118-121.
[12] 任孟群.慢性肝病患者睡眠质量的调查分析[J].湖南师范大学学报,2011,8(2):80-81.
[13] TEIXEIRA M C,RIBEIRO MDE F,GAYOTTO L C,et al.Worse quality of life in volunteer blood donors with hepatitis C[J].Transfusion,2006,46(2):278-283.
[14] AFENDY A,KALLMAN J B,STEPANOVA M,et al.Predictors of health-related quality of life in patients with chronic liverdisease[J].Aliment Pharmacol Ther,2009,30(5):469-476.
[15] HÄUSER W,HOLTMANN G,GRANDT D.Determinants of health-related quality of life in patients with chronic liver diseases[J].Clin Gastroenterol Hepatol,2004,2(2):157-163.
[16] de ALMEIDA C M,de LIMA T A,CASTRO D B,et al.Immunological/virological peripheral blood biomarkers and distinct patterns of sleeping quality in chronic hepatitis C patients[J].Scand J Immunol,2011,73(5):486-495.
[17] LIU C,XIE H,ZHANG X,et al.Health related management plans improvesleep disorders of patients with chronic liver disease[J].Int J Clin Exp Med,2015,8(6):9883-9889.