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生长分化因子-15在慢性心力衰竭中的研究进展
作者:陈晓云1  童嘉毅2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 心血管内科, 江苏 南京 210009
关键词:生长分化因子-15 慢性心力衰竭 诊断 预后判断 文献综述 
分类号:R541.6
出版年·卷·期(页码):2018·46·第七期(838-842)
摘要:

慢性心力衰竭已成为全球性医疗和公众健康问题,其发病率及死亡率极高。生物标记物的发展为心力衰竭的诊疗提供了巨大帮助,生长分化因子-15(GDF-15)是近年来研究发现的新型心衰检测标记物之一,它是一种分泌型应激蛋白,在心肌缺血缺氧、压力超负荷等状态下,诱导心肌细胞中GDF-15表达和分泌。GDF-15具有抑制细胞凋亡、细胞肥大和心脏重塑等作用,参与心力衰竭发生发展中多个病理生理学过程,在心力衰竭的诊断、危险分层及预后判断上发挥重要作用。作者对GDF-15在慢性心力衰竭中的研究进展作一综述。

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