Objective:To investigate the effects of L-carnitine on microcirculation and myocardial enzymes in patients undergoing off-pump coronary artery bypass surgery. Methods:A retrospective analysis was conducted on 80 patients who had undergone off-pump coronary artery bypass surgery in our hospital from January 2015 to January 2018. The patients were divided into observation group and control group with 40 cases in each group. Patients in the observation group were given L-carnitine before surgery, and patients in the control group were given the same volume of normal saline before surgery. The microcirculation and myocardial enzyme changes in venous blood were compared between the two groups after induction of anesthesia (T0), aortic wall forceps open for 30 min (T1), postoperative 12 h (T2) and 24 h (T3).Results:In both two groups, the levels of lactic acid (LA) in T2 and T3 were higher than those in T0, and the levels of oxygen saturation of mixed venose blood (SvO2) and mean arterial pressure (MAP) were lower than those of T0 (P<0.05). The levels of LA in the observation group at T2 and T3 were lower than those in the control group, and the levels of SvO2 and MAP in the observation group were higher than those in the control group at the same period (P<0.05). The levels of cardiac troponin (cTnI) and creatine kinase isoenzyme (CK-MB) in T1, T2 and T3 were significantly higher than those in T0 (P<0.05). The levels of cTnI and CK-MB in the observation group were lower than those in the control group at T1, T2 and T3 (P<0.05). In both two groups, the plasma superoxide dismutase (SOD) activity at T1, T2 and T3 was lower than that at T0, and the malondialdehyde (MDA) concentration at T1, T2 and T3 was higher than that at T0 (P<0.05). The plasma SOD activity of the observation group at T1, T2 and T3 was higher than that of the control group, and the MDA concentration was lower than that of the control group at the same period (P<0.05).Conclusion:L-carnitine has the effect of improving microcirculation and protecting myocardium in patients undergoing off-pump coronary artery bypass surgery. |