Objective:To investigate the safety and effectiveness of laparoscopy in patients with colorectal cancer and liver metastasis. Methods:66 colorectal cancer with liver metastasis patients admitted into our department from June 2015 to August 2017 were divided into 2 groups according to the surgical method:laparotomy group (n=33) and laparoscopic group (n=33). The patients in the laparotomy group underwent open surgery, the patients in the laparoscopic group underwent laparoscopy. The therapeutic effect of two groups was evaluated by WHO's tumor effect standard. The operation time, blood loss, anal exhaust time, hospitalization time and the time of postoperative chemotherapy were recorded. The incision infection, abdominal abscess, intestinal obstruction and gastrointestinal bleeding were recorded and statistically analyzed. The patients were followed up for 5 years. The cumulative postoperative survival rate of 1, 2 and 3 years, clinical efficacy, survival rate and safety of the two groups were compared. Results:The response rate of laparoscopic group was 33.33% (28/33), higher than 21.21%(21/33) of the laparotomy group (P<0.05). There was no significant differences between 2 groups in postoperative chemotherapy (P<0.05); Postoperative anal exhaust and hospital stay were shorter (less) in the laparotomy group (P<0.05),laparoscopic operation time was longer than that in the laparotomy group (P<0.05). while laparoscopic incision infection, the incidences of the abdominal abscess, intestinal obstruction and gastrointestinal bleeding were significantly lower in the laparoscopic group than those of the laparotomy group (P<0.05). The 1-year, 2-year and 3-year survival rates of the laparoscopic group were 81.82% (27/33) 69.70% (23/33) and 54.55%(18/33), respectively, which were significantly higher than those in the open surgery group 72.73%(24/33), 57.58%(19/33) and 30.30%(10/33) respectively(P<0.05). Compared with the laparotomy group, the survival rate of 3 years in the laparoscopic group were significantly higher (P<0.05). Conclusions:Laparoscopic surgery in patients with colorectal cancer and liver metastasis is helpful to improve the clinical curative effect, having the advantages of less traumatic operation and quick recovery after operation. It is helpful to improve the survival rate of patients and is worth popularizing and applying.
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