Objective:To investigate the early diagnosis of coronary heart disease by the combined detection of ischemia-modified albumin (IMA), lipoprotein-related phospholipase A2 (Lp-PLA2), high-sensitivity C-reactive protein (hs-CRP), and serum total cholesterol (TC). Methods:A total of 120 patients with coronary heart disease admitted to our hospital from July 2016 to July 2017 were selected. Forty patients with acute myocardial infarction (AMI), 40 patients with stable angina pectoris (SAP) and 40 patients with unstable angina pectoris 40 cases of unstable angina pectoris (UAP) were selected. At the same time, 40 healthy subjects in our hospital were selected into the control group. Blood was collected and the levels of IMA, Lp-PLA2, hs-CRP and TC in the blood were measured. Results:Compared with the control group, the levels of Lp-PLA2, hs-CRP and TC in patients with acute myocardial infarction (AMI group), stable angina pectoris (SAP group) and unstable angina pectoris (UAP group) were significantly lower, the difference was statistically significant (P<0.05).Compared with stable angina pectoris (SAP group), the levels of Lp-PLA2, hs-CRP and TC in AMI group and UAP group were increased significantly and the IMA content decreased significantly along with the severity of the disease, the difference was statistically significant (P<0.05).The positive rates of IMA, Lp-PLA2, hs-CRP and TC in serum of patients with acute myocardial infarction (AMI group), stable angina pectoris group (SAP group) and unstable angina pectoris group (UAP group),the detection rate and the difference were statistically significant (P<0.05). AMI group, SAP group and UAP group had significant negative correlation with serum IMA protein, Person correlation coefficient(-0.37,-0.35,-0.39) was negative, (P<0.01); There was a significant positive correlation between serum Lp-PLA2, hs-CRP and TC protein. Person's correlation coefficient was positive (P<0.01). Conclusion:The serum levels of Lp-PLA2, hs-CRP and TC in patients with coronary heart disease were significantly increased, and IMA levels were significantly decreased. The combined detection and real-time monitoring of IMA, Lp-PLA2, hs-CRP and TC have important clinical significance in the diagnosis of coronary heart disease. |