目的：探究妊娠合并精神分裂症与产妇和新生儿结局之间的关系。方法：选择2013年5月至2017年3月于我院产科分娩合并有精神分裂症的产妇65例作为研究对象，选择同期健康产妇60例作为对照，收集所有孕妇的资料（妊娠期间复发入院、妊娠期并发症、妊娠期合并症、分娩期并发症、新生儿结局等），比较妊娠合并精神分裂症产妇与健康产妇各项指标之间的差异。比较妊娠合并精神分裂症产妇妊娠期间复发者与非复发者妊娠、新生儿结局之间的差异。结果：妊娠合并精神分裂症产妇及新生儿各项不良结局的发生率均显著高于健康对照组；妊娠合并精神分裂症产妇中27例（41.5%）在妊娠期间因疾病复发入院治疗，其中一半以上的产妇（14例，51.9%）在妊娠早期入院，入院人数显著多于妊娠晚期入院者（P=0.010）。复发组产妇与非复发组相比，产检时间晚、产检次数少；产妇妊娠子痫的发病率、新生儿入NICU的比例均显著高于非复发组；其他各项不良指标的发生率与非复发组相比差异无统计学意义。结论：妊娠合并精神分裂症是产妇、新生儿发生不良结局的危险因素，妊娠期间疾病复发入院的产妇其妊娠、新生儿不良结局的危险性高于非复发者。

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